{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:54:01Z","timestamp":1782446041923,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The gastroparetic syndrome encompasses antral hypomotility, gastric dysrhythmia, impaired antroduodenal coordination, pyloric dysfunction, and abnormal duodenal motility; the last three collectively referred to as pylorospasms. We hypothesized that antroduodenal motility is diminished and transition time is prolonged in adults with type 1 diabetes (T1D) and polyneuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 124 participants, of which 21 were healthy, 53 had T1D and 50 had T1D with distal symmetrical polyneuropathy (T1D + DSPN). We used the wireless motility capsule to assess antroduodenal transition time, gastric emptying time, gastric and small bowel motility indices (MI), and numbers of alkalic\/acidic exposures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with controls, patients with T1D had prolonged antroduodenal transition time (1.85\u00b11.5 vs. 6.6\u00b14.8 minutes; <jats:italic>p<\/jats:italic>=0.02), which was even more pronounced in patients with T1D+DSPN (1.85\u00b11.5 vs. 17.8\u00b128.5 minutes; <jats:italic>p<\/jats:italic>&lt;0.008. T1D+DSPN tended to have diminished gastric MI (11.9\u00b12.4 vs. 12.7\u00b11.0, <jats:italic>p<\/jats:italic>=0.07) and small bowel MI (13.1\u00b11.4 vs. 13.6\u00b10.6, <jats:italic>p<\/jats:italic>=0.05) and experienced more antral\/pyloric alkalic episodes (1.2\u00b11.3 vs. 2.0\u00b12.1, <jats:italic>p<\/jats:italic>=0.02) compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current method may assess a proxy for severity of pylorospasms in patients with diabetes and other diseases associated with upper gastrointestinal motility disorders, which ultimately may optimize future management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14144","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T02:57:46Z","timestamp":1619060266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The antroduodenal transition time is prolonged in adults with type 1 diabetes"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-1884","authenticated-orcid":false,"given":"Christina","family":"Brock","sequence":"first","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"},{"name":"Clinical Institute Aalborg University Aalborg Denmark"},{"name":"Steno Diabetes Center North Jutland Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-6537","authenticated-orcid":false,"given":"Donghua","family":"Liao","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-4843","authenticated-orcid":false,"given":"Anne\u2010Marie","family":"Wegeberg","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-964X","authenticated-orcid":false,"given":"Asbj\u00f8rn","family":"Mohr Drewes","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"},{"name":"Clinical Institute Aalborg University Aalborg Denmark"},{"name":"Steno Diabetes Center North Jutland Aalborg University Hospital Aalborg 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