{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:20:08Z","timestamp":1782480008868,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rumination syndrome has been associated with increased duodenal eosinophils and intraepithelial lymphocytes in adults. The aims of the current study were to assess densities of antroduodenal eosinophils and mast cells and duodenal intraepithelial lymphocytes in youth with rumination syndrome and to compare cell densities in those with and without abdominal pain or early satiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight youth fulfilling Rome IV criteria for rumination syndrome who had undergone endoscopy were identified and compared to 10 controls. Antral and duodenal biopsies were assessed to determine densities of eosinophils, mast cells, and intraepithelial lymphocytes. Cell densities were also compared between rumination patients with and without abdominal pain and those with and without early satiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>Antral mast cell (peak 18.5\u00b16.5 vs. 12.5\u00b12.7) and eosinophil (peak 9.6\u00b15.2 vs. 4.9\u00b12.1) densities were significantly greater in patients with rumination syndrome as compared to controls. Duodenal intraepithelial lymphocyte densities were also increased in rumination syndrome (18.9 \u00b1 5.1 vs. 11.7 \u00b1 1.5; <jats:italic>p<\/jats:italic>&lt;.001). Associations were independent of the presence of abdominal pain or early satiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>In conclusion, we found an increase in eosinophil and mast cell densities in the gastric antrum and an increase in intraepithelial lymphocytes in the duodenum in youth with rumination syndrome which was independent of the presence of abdominal pain or early satiety. These findings suggest a potential role for inflammation in the pathophysiology of rumination syndrome. Future studies should address whether treatment directed at these cells are beneficial in treating rumination syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14155","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T15:14:25Z","timestamp":1618067665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mucosal eosinophils, mast cells, and intraepithelial lymphocytes in youth with rumination syndrome"],"prefix":"10.1111","volume":"33","author":[{"given":"Hunter J.","family":"Friesen","sequence":"first","affiliation":[{"name":"School of Medicine University of Kansas Kansas City KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, &amp; Nutrition Children\u2019s Mercy Kansas City MO USA"},{"name":"Department of Pediatrics University of Missouri\u2010Kansas City School of Medicine Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Low Kapalu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, &amp; 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