{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:37:01Z","timestamp":1792471021194,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lidocaine is commonly applied to improve the tolerance of esophageal manometry (EM) and ambulatory pH monitoring (PM). We recently published data suggesting a benefit to this practice and we aimed to confirm these findings in a randomized trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a double\u2010blind, randomized trial of lidocaine nasal spray versus placebo (saline) before EM and PM. Patients referred to our center who met inclusion criteria were enrolled. Patients were asked to fill a questionnaire after their test and patient\u2010reported adverse effects were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Three hundred and four patients were enrolled in our trial. Lidocaine and placebo groups were demographically similar. The primary outcome, pain during catheter insertion, occurred in 60\/148 (40.5%) patients in the lidocaine group versus in 72\/152 (47.4%) patients in the placebo group (OR: 0.76 [95% CI: 0.48\u20131.20]; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.23). Patients receiving lidocaine were less likely to report nausea during test recording (OR: 0.48 [95% CI: 0.24\u20130.91]; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.02) and reported slightly lower intensity of pain during both catheter insertion and test recording (4.68\u00a0\u00b1\u00a02.06 versus 5.41\u00a0\u00b1\u00a02.24 on 10; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.048 and 3.71\u00a0\u00b1\u00a02.00 versus 4.93\u00a0\u00b1\u00a02.55 on 10; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.03, respectively). Furthermore, patients receiving lidocaine were less likely to report their test as globally uncomfortable and painful (57% vs. 75%; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.003 and 14% vs. 21%; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.02, respectively). No events of systemic lidocaine toxicity occurred during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine use of lidocaine before esophageal function tests does not reduce pain during catheter insertion but may provide other modest benefits with limited toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14167","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T11:47:48Z","timestamp":1620647268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lidocaine before esophageal manometry and ambulatory pH monitoring: A randomized controlled trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-6219","authenticated-orcid":false,"given":"George","family":"Wahba","sequence":"first","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissaveta","family":"Neshkova","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-3880","authenticated-orcid":false,"given":"Gabrielle","family":"Jutras","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2486-3647","authenticated-orcid":false,"given":"Jeremy","family":"Liu Chen Kiow","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-6181","authenticated-orcid":false,"given":"Marianne","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Willems","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny\u2010Darold","family":"Eouani","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Courbette","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lo\u00efse","family":"Ayuso","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Bouin","sequence":"additional","affiliation":[{"name":"Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13687"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"137","article-title":"Usefulness of gel lidocaine in esophageal manometry","volume":"66","author":"Carmona\u2010Sanchez R","year":"2001","journal-title":"Rev Gastroenterol Mex"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5036160"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.9.1177"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu115"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009746"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.02.022"},{"key":"e_1_2_10_10_1","unstructured":"TutuianR CastellDO.Gastroesophageal reflux monitoring: pH and impedance. GI Motility online.2006."},{"issue":"6","key":"e_1_2_10_11_1","first-page":"515","article-title":"Evidence\u2010Based Surgery Working G. How to work with a subgroup analysis","volume":"52","author":"Dijkman B","year":"2009","journal-title":"Can J Surg"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1992.tb03554.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet127"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acpain.2007.07.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365248"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00160"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0239-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00674K"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"96","article-title":"Reducing the flavour of oral lidocaine: randomized controlled trial assessing the efficacy of mint\u2010flavoured mouthwash","volume":"39","author":"Bonaparte JP","year":"2010","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2005.04.005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267062"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07750-4"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:24:31Z","timestamp":1693211071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/nmo.14167"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14167","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]},"assertion":[{"value":"2020-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14167"}}