{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:08:50Z","timestamp":1777363730003,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are little data evaluating the performance of the 3\u2010dimensional high\u2010definition anorectal manometry (3D\u2010HDAM) system in the diagnosis of dyssynergic defecation. Physical properties of the thicker, rigid, 3D\u2010HDAM probe may have implications on the measurements of anorectal pressures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to compare 3D\u2010HDAM to balloon expulsion test and magnetic resonance (MR) defecography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive constipated patients referred for anorectal function testing at the Calgary Gut Motility Centre (Calgary, Canada) between 2014 and 2019 were assessed. All patients underwent anorectal manometry with the 3D\u2010HDAM probe, and a subset underwent BET or MR defecography. Anorectal manometric variables were compared between patients who had normal and abnormal BET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the study period, 81 patients underwent both 3D\u2010HDAM and BET for symptoms of constipation. 52 patients expelled the balloon within 3 minutes. Patients with abnormal BET had significantly lower rectoanal pressure differential (RAPD) (\u221261 vs. \u221231\u00a0mmHg for normal BET,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and defecation index (0.29 vs. 0.56, p\u00a0=\u00a00.03). On logistic regression analysis, RAPD (OR: 0.99, 95% CI: 0.97\u20130.99, p\u00a0=\u00a00.03) remained a negative predictor of abnormal BET. On ROC analysis, RAPD had an AUC of 0.65. There was good agreement between dyssynergic patterns on 3D\u2010HDAM and defecographic evidence of dyssynergia (sensitivity 80%, specificity 90%, PLR 9, NLR 0.22, accuracy 85%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Manometric parameters, when measured with the 3D\u2010HDAM probe, poorly predict prolonged balloon expulsion time. RAPD remains the best predictor of prolonged balloon expulsion time. The 3D\u2010HDAM probe may not be the ideal tool to diagnose functional defecatory disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14180","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T13:27:34Z","timestamp":1623677254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Manometric parameters, when measured with the 3\u2010dimensional high\u2010definition anorectal manometry probe, poorly predict prolonged balloon expulsion time"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-3420","authenticated-orcid":false,"given":"Matthew","family":"Woo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armaan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harman","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-1901","authenticated-orcid":false,"given":"Michelle","family":"Buresi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Calgary Calgary AB 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