{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:18:39Z","timestamp":1787761119277,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The low FODMAPs (fermentable oligo\u2010, di\u2010, monosaccharides, and polyols) diet improves lower gastrointestinal symptoms. Patients suffering from proton pump inhibitor (PPI) refractory gastroesophageal reflux disease (GERD) have limited treatment options. We investigated the efficacy of a low FODMAPs diet in patients with PPI refractory GERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, randomized, open\u2010label study compared the efficacy of a 4\u2010week low FODMAPs diet and usual dietary advice (<jats:italic>ie<\/jats:italic>, low\u2010fat diet and head of bed elevation) in patients with symptomatic PPI refractory GERD, defined by a Reflux Disease Questionnaire (RDQ) score &gt;3 and abnormal pH\u2010impedance monitoring on PPIs. The primary endpoint was the percentage of responders (RDQ \u22643) at the end of the diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients (55% women, median age 45\u00a0years) were included, 16 randomized in the low FODMAPs diet group and 15 in the usual dietary advice group. Adherence to the assigned diet was good, with a significant difference in the FODMAPs intake per day between the low FODMAPs diet (2.5\u00a0g) and the usual dietary advice group (13\u00a0g) (p\u00a0&lt;\u00a00.001). There was no difference in response rates (RDQ score \u22643) between the low FODMAPs diet (6\/16, 37.5%) and usual dietary advice (3\/15, 20%) groups (p\u00a0=\u00a00.43). Total RDQ score and dyspepsia subscore decreased significantly over time in both groups (p\u00a0=\u00a00.002), with no difference according to the assigned diet group (p\u00a0=\u00a00.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low FODMAPs diet and usual dietary advice have similar but limited beneficial effects on symptoms in patients with PPI refractory GERD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14181","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T12:01:54Z","timestamp":1622808114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Low FODMAPs diet or usual dietary advice for the treatment of refractory gastroesophageal reflux disease: An open\u2010labeled randomized trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-2806","authenticated-orcid":false,"given":"Pauline","family":"Rivi\u00e8re","sequence":"first","affiliation":[{"name":"Centre M\u00e9dico\u2010Chirurgical Magellan H\u00f4pital Haut\u2010L\u00e9v\u00eaque CHU de Bordeaux Bordeaux France"},{"name":"INSERM CIC 1401 Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Vauquelin","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dico\u2010Chirurgical Magellan H\u00f4pital Haut\u2010L\u00e9v\u00eaque CHU de Bordeaux Bordeaux France"},{"name":"INSERM CIC 1401 Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliane","family":"Rolland","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dico\u2010Chirurgical Magellan H\u00f4pital Haut\u2010L\u00e9v\u00eaque CHU de Bordeaux Bordeaux France"},{"name":"INSERM CIC 1401 Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Melchior","sequence":"additional","affiliation":[{"name":"Gastroenterology Department and INSERM CIC\u2010CRB 1404 Rouen University Hospital Rouen Cedex France"},{"name":"INSERM UMR 1073 Institute for Research and Innovation in Biomedicine Normandy University Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7638","authenticated-orcid":false,"given":"Sabine","family":"Roman","sequence":"additional","affiliation":[{"name":"Digestive Physiology Hopital E Herriot Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"},{"name":"Inserm U1032 LabTAU Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Bruley des Varannes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department CHU de Nantes Institut des Maladies de l'Appareil Digestif IMAD CIC 1413 Universit\u00e9 de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Mion","sequence":"additional","affiliation":[{"name":"Digestive Physiology Hopital E Herriot Hospices Civils de Lyon Universit\u00e9 de Lyon Lyon France"},{"name":"Inserm U1032 LabTAU Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9155","authenticated-orcid":false,"given":"Guillaume","family":"Gourcerol","sequence":"additional","affiliation":[{"name":"INSERM UMR 1073 Institute for Research and Innovation in Biomedicine Normandy University Rouen France"},{"name":"Physiology Department and INSERM CIC\u2010CRB 1404 Rouen University Hospital Rouen Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Sacher\u2010Huvelin","sequence":"additional","affiliation":[{"name":"Gastroenterology Department CHU de Nantes Institut des Maladies de l'Appareil Digestif IMAD CIC 1413 Universit\u00e9 de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-2121","authenticated-orcid":false,"given":"Frank","family":"Zerbib","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dico\u2010Chirurgical Magellan H\u00f4pital Haut\u2010L\u00e9v\u00eaque CHU de Bordeaux Bordeaux France"},{"name":"INSERM CIC 1401 Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.06.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318260"},{"issue":"6","key":"e_1_2_9_5_1","first-page":"G1266","article-title":"Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans. 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