{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:26:12Z","timestamp":1794108372312,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Quarantine with social distancing has reduced transmission of COVID\u201019; however, fear of the disease and these remedial measures cause anxiety and stress. It is not known whether these events have impacted the prevalence of gastrointestinal (GI) symptoms and disorders of brain\u2010gut interaction (DGBI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online platform evaluated the prevalence of GI symptoms during the COVID\u201019 pandemic. Data collection utilized validated questionnaires and was fully anonymized. Findings were compared with identical data acquired in 2019. The association of results with stress and anxiety was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected from 1896 subjects May \u2010 August 2019 to 980 non\u2010identical subjects May \u2010 June 2020. GI symptoms were reported by 68.9% during the COVID\u201019 lockdown compared with 56.0% the previous year (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). The prevalence of irritable bowel syndrome (26.3% vs. 20.0%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), functional dyspepsia (18.3% vs. 12.7%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), heartburn (31.7% vs. 26.2%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.002), and self\u2010reported milk intolerance (43.5% vs. 37.8% <jats:italic>p\u00a0<\/jats:italic>=\u00a00.004) was higher during the pandemic. Many individuals reported multiple symptoms. Anxiety was associated with presence of all GI symptoms. High levels of stress impacted functional dyspepsia (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.045) and abdominal pain (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.013). The presence of DGBI (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001; OR 22.99), self\u2010reported milk intolerance (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001; OR 2.50), and anxiety (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001; OR 2.18) was independently associated with increased GI symptoms during COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of GI symptoms was significantly higher during the COVID\u201019 lockdown than under normal circumstances the previous year. This increase was attributable to increased numbers of patients with DGBI, an effect that was associated with anxiety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14197","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T05:14:03Z","timestamp":1624079643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Increased prevalence of gastrointestinal symptoms and disorders of gut\u2010brain interaction during the COVID\u201019 pandemic: An internet\u2010based survey"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-8417","authenticated-orcid":false,"given":"Radislav","family":"Nakov","sequence":"first","affiliation":[{"name":"Clinic of Gastroenterology Tsaritsa Yoanna University Hospital Medical University of Sofia Sofia 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Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Digestive Function: Basel Laboratory and Clinic for Motility Disorders and Functional Digestive Diseases Center for Integrative Gastroenterology Arlesheim Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-0921","authenticated-orcid":false,"given":"Henriette","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Z\u00fcrich Z\u00fcrich 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