{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:29:58Z","timestamp":1790101798920,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric electrical stimulation (GES) is a promising therapy for children with severe nausea and vomiting, but information on long\u2010term outcomes is limited. We sought to evaluate the long\u2010term efficacy and safety of GES and to describe patient benefit and satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a prospective registry, we identified patients aged &lt;21\u00a0years treated with GES at our institution between 2009 and 2019. Encounters were selected at baseline prior to GES and at follow\u2010up at 1\u00a0month, 12\u00a0months, and the most recent visit. We compared symptoms, route of nutrition, and medication usage at baseline to follow\u2010up timepoints. Factors associated with improvement were evaluated. We recorded complications and need for battery replacement. We contacted families to administer the Glasgow Children's Benefit Inventory (GCBI) and a parent satisfaction questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Eighty\u2010five patients (68.2% female, median age 15.8\u00a0years) completed a trial of temporary GES due to severe nausea and vomiting. Seventy\u2010seven (90.6%) had a positive response and underwent permanent stimulator placement. Use of tube feeding or parenteral nutrition (PN) decreased from 72.7% at baseline to 29.9% at the most recent follow\u2010up (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Higher baseline vomiting severity was associated with the ability to stop supplemental nutrition by 1\u00a0month (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Fourteen patients (18.2%) had complications, primarily due to stimulator\u2010associated discomfort, and 29 (37.7%) required battery replacement. Median GCBI was +52.1, indicating health\u2010related benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Children with severe nausea and vomiting treated with GES experienced significant and durable improvement in symptom severity and their ability to tolerate oral nutrition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14199","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T10:53:26Z","timestamp":1623754406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten\u2010year experience"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-8155","authenticated-orcid":false,"given":"Danielle K.","family":"Orsagh\u2010Yentis","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"},{"name":"The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hurwitz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"},{"name":"The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Diefenbach","sequence":"additional","affiliation":[{"name":"Center for Colorectal and Pelvic Reconstruction Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Teich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Levine Children\u2019s Hospital Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayat","family":"Mousa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Department of Pediatrics University of Pennsylvania The Children\u2019s Hospital of Philadelphia Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Bali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Vaz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desale","family":"Yacob","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-3353","authenticated-orcid":false,"given":"Peter L.","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000394"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12260"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04082.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13534"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.04.032"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.2.131"},{"key":"e_1_2_8_8_1","unstructured":"US Food and Drug Administration.Gastric electrical stimulation (GES) system. 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