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Investigative approaches, such as propulsion of artificial pellets in preparations of whole colon in organ baths <jats:italic>in vitro<\/jats:italic> and innovative approaches capitalizing on neurogenetic technologies (eg, optogenetics), are considered in view of potential application in the development of novel therapeutic mechanisms to selectively evoke and control gastrointestinal motility patterns, such as the small intestinal digestive motility pattern, interdigestive pattern, and reversed direction of powerful propulsive motility during emesis. This minireview relates to the paper titled: \u201c<jats:italic>Motor patterns in the proximal and distal mouse colon which underlie formation and propulsion of feces<\/jats:italic>,<jats:italic>\u201d<\/jats:italic> appearing in this issue of <jats:italic>Neurogastroenterology and Motility<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/nmo.14206","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T11:39:02Z","timestamp":1624102742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Motor behavior of mouse large intestine: A Minireview"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-7656","authenticated-orcid":false,"given":"Jackie Dale","family":"Wood","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology College of Medicine The Ohio State University  Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"565","volume-title":"Laboratory Experiments in Physiology","author":"Zoethout WD","year":"1940"},{"issue":"4","key":"e_1_2_12_3_1","first-page":"1","article-title":"The curious case of the decapitated frog: on experiment and philosophy","volume":"26","author":"Klein A","year":"2017","journal-title":"Br J Hist Philos"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071956"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076598"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.65881-6"},{"key":"e_1_2_12_7_1","first-page":"201","article-title":"Neurotransmission at the interface of sympathetic and enteric divisions of the autonomic nervous system","volume":"42","author":"Wood J","year":"1999","journal-title":"Chinese J Physiol"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.43.030181.000341"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700730228"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1962.44"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a107457"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382026-6.00022-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809954-4.00015-3"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1970.218.3.762"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00463.2020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00317.2020"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14047"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00185.2019"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1972.222.1.118"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01318696"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296056"},{"key":"e_1_2_12_22_1","first-page":"590","article-title":"Effects of atropine, tetrodotoxin and xylocaine on rebound excitation of guinea\u2010pig small intestine","volume":"184","author":"Wood JD","year":"1973","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.15.648"},{"key":"e_1_2_12_24_1","first-page":"35","article-title":"Effects of destruction of intramural ganglion cells on colon motility: Possible genesis of congenital megacolon","volume":"116","author":"Hukuhara T","year":"1961","journal-title":"Jap J Physiology"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02232959"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02232960"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296453"},{"issue":"8","key":"e_1_2_12_28_1","first-page":"e4291429","article-title":"Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine","volume":"12","author":"Li Z","year":"2019","journal-title":"eLife"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.029"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1581061"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102733"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14047"}],"container-title":["Neurogastroenterology &amp; 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