{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:40:18Z","timestamp":1778931618339,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008733","name":"H\u00f8rslev-Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Neurotensin (NT) is released from enteroendocrine cells and lowers food intake in rodents. We evaluated postprandial NT secretion in humans after surgeries associated with accelerated small intestinal nutrient delivery, and after Roux\u2010en\u2010Y gastric bypass (RYGB) when glucagon\u2010like peptide\u20101 (GLP\u20101) signalling and dipeptidyl peptidase 4 (DPP\u20104) were inhibited, and during pharmacological treatments influencing entero\u2010pancreatic functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured NT concentrations in plasma from meal studies: (I) after truncal vagotomy with pyloroplasty (TVP), cardia resection +TVP (CTVP), and matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a010); (II) after RYGB, sleeve gastrectomy (SG), and in matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a012); (III) after RYGB (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) with antagonism of GLP\u20101\u00a0signalling using exendin(9\u201339) and DPP\u20104 inhibition using sitagliptin; (IV) after RYGB (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) during a run\u2010in period and subsequent treatment with, sitagliptin, liraglutide (GLP\u20101 receptor agonist), verapamil (calcium antagonist), acarbose (alpha glucosidase inhibitor), and pasireotide (somatostatin analogue), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(I) NT secretion was similar after TVP\/CTVP (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.9), but increased vs. controls (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). (II) NT secretion was increased after RYGB vs. SG and controls (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). NT responses were similar in SG and controls (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.3), but early postprandial NT concentrations were higher after SG (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). (III) Exendin (9\u201339) and sitagliptin did not change NT responses vs placebo (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.2), but responses were lower during sitagliptin vs. exendin(9\u201339) (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.03). (IV) Pasireotide suppressed NT secretion (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.004). Sitagliptin tended to lower NT secretion (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.08). Liraglutide, verapamil, and acarbose had no effect (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neurotensin secretion is increased after surgeries associated with accelerated gastric emptying and lowered by pasireotide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14210","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T10:17:20Z","timestamp":1628677040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neurotensin secretion after Roux\u2010en\u2010Y gastric bypass, sleeve gastrectomy, and truncal vagotomy with pyloroplasty"],"prefix":"10.1111","volume":"34","author":[{"given":"Maria S.","family":"Svane","sequence":"first","affiliation":[{"name":"Department of Endocrinology Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research 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