{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:38:55Z","timestamp":1753879135027,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nasogastric (NG) intubation for esophageal manometry can be traumatic and may be associated with a temporary reduction\/absence in esophageal peristalsis. This study explored the prevalence and effect on esophageal motor function. We also hypothesized that baseline anxiety as well as markers of autonomic nerve function were correlated to attenuated esophageal peristalsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven patients with esophageal symptoms referred for esophageal manometry investigation (mean age 56.8\u00a0\u00b1\u00a016.7\u00a0years, range 23\u201385\u00a0years) reported baseline anxiety score (Likert scale) preintubation. Patients had continuous heart rate and blood pressure measured prior to intubation and until 10\u00a0min after catheter withdrawal. Quality of motility was assessed for each 5\u00a0ml water swallow using standard Chicago Classification metrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Nasogastric\u2010intubation elicited a significant increase in heart rate (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), systolic (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and diastolic (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) blood pressure, which was in part anticipatory. The median time taken for patients' first hypotensive peristalsis (Distal Contractile Integral; DCI \u2265100\u00a0mmHg\u00a0s\u00a0cm) was 130\u00a0s (Interquartile range; 47\u2013242\u00a0s) and for their first normal peristalsis (DCI \u2265450\u00a0mm\u00a0Hg\u00a0s\u00a0cm) was 150\u00a0s (IQR 61\u2010320\u00a0s), with improvement and consistent stabilization in DCI there onward. This corresponded closely to the time for initial recovery of heart rate and systolic and diastolic blood pressure postintubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Nasogastric intubation resulted in heightened sympathetic responses and\/or dampened parasympathetic responses, and an associated temporary reduction or absence in esophageal peristalsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14214","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T03:32:01Z","timestamp":1627875121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An investigation into the effect of nasogastric intubation on markers of autonomic nervous function"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0356-9919","authenticated-orcid":false,"given":"Humayra","family":"Abdul\u2010Razakq","sequence":"first","affiliation":[{"name":"GI Physiology Unit University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Brugaletta","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Sweis","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8217-3487","authenticated-orcid":false,"given":"Stephen","family":"Perring","sequence":"additional","affiliation":[{"name":"Poole Hospital NHS Foundation Trust Poole UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD004929","article-title":"Prophylactic nasogastric decompression after abdominal surgery","volume":"3","author":"Nelson R","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2015.24.3.138"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.966683"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.11.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9941.68581"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12231"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"e14058","DOI":"10.1111\/nmo.14058","article-title":"Esophageal motility disorders on high\u2010resolution manometry: Chicago classification version 4.0","volume":"33","author":"Yadlapati R","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/737062"},{"key":"e_1_2_8_11_1","unstructured":"AGIP.British Society of Gastroenterology. 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