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We provide here our expert opinion on the North American, Australian and Asian assessments of the same topics discussed, and provide evidence where the ESNM consensus may deviate from those in the other continents. New and exciting data about the pathogenesis of FD are emerging including the possible central role of duodenal micro\u2010inflammation (most notably eosinophilic duodenitis and intestinal mast cell disease), but this is a very dynamic field with several gaps remaining in our understanding that are summarized in this review. Identification of non\u2010invasive biomarkers and testing of targeted therapies, including assessing the benefits of multidisciplinary teams in the management of FD, should be future priorities.<\/jats:p>","DOI":"10.1111\/nmo.14216","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T05:01:13Z","timestamp":1627880473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional dyspepsia: A critical appraisal of the European consensus from a global perspective"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-7134","authenticated-orcid":false,"given":"Baha","family":"Moshiree","sequence":"first","affiliation":[{"name":"Atrium Health Division of Gastroenterology, Hepatology and Nutrition Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-3092","authenticated-orcid":false,"given":"Nicholas J.","family":"Talley","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Newcastle NSW Australia"},{"name":"NHMRC Centre of Research Excellence in Digestive Health Newcastle NSW Australia"},{"name":"Australian GI Research Alliance (AGIRA Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia. 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