{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:08:11Z","timestamp":1775902091570,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stressful events during infancy may predispose to the development of functional gastrointestinal disorders (FGIDs) in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the association of necrotizing enterocolitis (NEC) with childhood FGIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a study, comparing 29 children of eight to ten years with a history of NEC with 58 children with no history of NEC. Subjects were assessed for FGIDs, based on Rome\u2010III criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 29\u00a0subjects with NEC, 17\u00a0had surgical and 12 conservative NEC. Subjects with surgically, or conservatively managed NEC developed FGIDs at a significantly higher proportion, as compared to children with no history of NEC, later in childhood (41%, 33%, and 13% respectively, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.033). Functional constipation was the most frequently identified disorder (35%, 33%, and 7% respectively). A significant association was detected between FGIDs and the history of perinatal stress (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.049), NEC (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.011), and the surgical management of NEC (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that there is a potential association between NEC and FGIDs later in childhood with functional constipation being the most frequently identified disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14222","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T11:13:16Z","timestamp":1630494796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Is there an association between necrotizing enterocolitis in premature neonates and functional gastrointestinal disorders later in childhood?"],"prefix":"10.1111","volume":"34","author":[{"given":"Dimitrios","family":"Rallis","sequence":"first","affiliation":[{"name":"2nd Neonatal Intensive Care Unit and Neonatology Department School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-6530","authenticated-orcid":false,"given":"Efstratios","family":"Saliakellis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Paediatric Gastroenterology School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Kaselas","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Malakozi","sequence":"additional","affiliation":[{"name":"2nd Neonatal Intensive Care Unit and Neonatology Department School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Spyridakis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Fotoulaki","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Paediatric Gastroenterology School of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisavet","family":"Diamanti","sequence":"additional","affiliation":[{"name":"2nd Neonatal Intensive Care Unit and 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