{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:47:53Z","timestamp":1785811673503,"version":"3.56.0"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aerosol spread is key to interpret the risk of viral contamination during clinical procedures such as esophageal high\u2010resolution manometry (HRM). Installing an air purifier seems a legitimate strategy, but this has recently been questioned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing an HRM procedure at the Leuven University Hospital were included in this clinical study. All subjects had to wear a surgical mask which was only lowered beneath the nose during the placement and removal of the nasogastric catheter. The number of aerosol particles was measured by a Lasair<jats:sup>\u00ae<\/jats:sup> II Particle Counter to obtain data about different particles sizes: 0.3; 0.5; 1.0; 3.0; 5.0; and 10.0\u00a0\u00b5m. Measurements were done immediately before the placement and the removal of the HRM catheter, and one and 5\u00a0min after. A portable air purifier with high\u2010efficiency particle air filters was installed in the hospital room.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Thirteen patients underwent a manometry examination. The amount of 0.3\u00a0\u00b5m\u2010sized particles was unaffected during the whole procedure. The larger particle sizes (1.0; 3.0; 5.0; and 10.0\u00a0\u00b5m) decreased when the catheter was positioned, but not 0.5\u00a0\u00b5m. During the HRM measurements itself, these numbers decreased further. Yet, 1\u00a0min after catheter removal a significant elevation of particles was seen, which did not recover within 5\u00a0min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Interferences<\/jats:title><jats:p>Based on this study, there is no evidence that filtration systems reduce aerosol particles properly during a clinical investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14227","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T02:13:28Z","timestamp":1627956808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of an air purifier on aerosol generation measurements during clinical motility testing"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-4636","authenticated-orcid":false,"given":"Wout","family":"Verbeure","sequence":"first","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-3263","authenticated-orcid":false,"given":"Annelies","family":"Geeraerts","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-6180","authenticated-orcid":false,"given":"I\u2010Hsuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"},{"name":"Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Timmermans","sequence":"additional","affiliation":[{"name":"Neurogastroenterology and motility University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joran","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-932X","authenticated-orcid":false,"given":"Hannelore","family":"Geysen","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cools","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-7904","authenticated-orcid":false,"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"},{"name":"Neurogastroenterology and motility University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-969X","authenticated-orcid":false,"given":"Jolien","family":"Schol","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Devriese","sequence":"additional","affiliation":[{"name":"Prevention and Environment University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico","family":"Haesaerts","sequence":"additional","affiliation":[{"name":"Neurogastroenterology and motility University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-4671","authenticated-orcid":false,"given":"Hideki","family":"Mori","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8728-0903","authenticated-orcid":false,"given":"Tim","family":"Vanuytsel","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"},{"name":"Neurogastroenterology and motility University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders KU Leuven  Leuven Belgium"},{"name":"Neurogastroenterology and motility University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13930"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2004973"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2020027"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0516"},{"key":"e_1_2_8_6_1","unstructured":"Agency USEPWill an air cleaner or air purifier help protect me and my family from COVID\u201019 in my home?: United States goverment; 2020 [updated January 12 2021.https:\/\/www.epa.gov\/coronavirus\/will\u2010air\u2010cleaner\u2010or\u2010air\u2010purifier\u2010help\u2010protect\u2010me\u2010and\u2010my\u2010family\u2010covid\u201019\u2010my\u2010home.Accessed February 17 2021."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323836"}],"container-title":["Neurogastroenterology &amp; 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