{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:20:42Z","timestamp":1789050042817,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016145","name":"Ministerio de Sanidad, Consumo y Bienestar Social","doi-asserted-by":"publisher","award":["PI14\/01703"],"award-info":[{"award-number":["PI14\/01703"]}],"id":[{"id":"10.13039\/100016145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Grading dysphagia is crucial for clinical management of patients. The Eckardt score (ES) is the most commonly used for this purpose. We aimed to compare the ES with the recently developed Brief Esophageal Dysphagia Questionnaire (BEDQ) in terms of their correlation and discriminative capacity for clinical and manometric findings and evaluate the effect of gastroesophageal reflux symptoms on both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Symptomatic patients referred for high\u2010resolution manometry (HRM) were prospectively recruited from seven centers in Spain and Latin America. Clinical data and several scores (ES, BEDQ, GERDQ) were collected and contrasted to HRM findings. Standard statistical analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>426 patients were recruited, 31.2% and 41.5% being referred exclusively for dysphagia and GERD symptoms, respectively. Both BEDQ and ES were independently associated with achalasia. Only BEDQ was independently associated with being referred for dysphagia and with relevant HRM findings. ROC curve analysis for achalasia diagnosis showed AUC of 0.809 for BEDQ and 0.765 for ES, with the main difference being higher BEDQ sensitivity (80.0% vs 70.8% for ES). GERDQ independently predicted ES but not BEDQ. In the absence of dysphagia (BEDQ\u00a0=\u00a00), GERD symptoms significantly determine ES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Our study suggests both the BEDQ and ES can complementarily describe symptomatic burden in achalasia. BEDQ has several advantages over the ES in the dysphagia evaluation, basically due to its higher sensitivity for manometric diagnosis and independence of GERD symptoms. ES should be used as an achalasia\u2010specific metric, while BEDQ is a better symptom\u2010generic evaluating tool.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14228","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T02:08:57Z","timestamp":1627956537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Brief Esophageal Dysphagia Questionnaire shows better discriminative capacity for clinical and manometric findings than the Eckardt score: Results from a multicenter study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-5192","authenticated-orcid":false,"given":"Daniel","family":"Cisternas","sequence":"first","affiliation":[{"name":"Cl\u00ednica Alemana de Santiago Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-2441","authenticated-orcid":false,"given":"Tiffany","family":"Taft","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-7758","authenticated-orcid":false,"given":"Dustin A.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Glasinovic","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Alemana de Santiago Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-3945","authenticated-orcid":false,"given":"Hugo","family":"Monrroy","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rey","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albis","family":"Hani","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Ardila\u2010Hani","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00a0Maria","family":"Leguizamo","sequence":"additional","affiliation":[{"name":"San Ignacio Hospital Pontificia Universidad Javeriana Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bilder","sequence":"additional","affiliation":[{"name":"Hospital Universitario Escuela de Medicina Fundaci\u00f3n Favaloro Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Ditaranto","sequence":"additional","affiliation":[{"name":"Hospital Universitario Escuela de Medicina Fundaci\u00f3n Favaloro Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Varela","sequence":"additional","affiliation":[{"name":"Hospital Universitario Escuela de Medicina Fundaci\u00f3n Favaloro Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Agotegaray","sequence":"additional","affiliation":[{"name":"Hospital Universitario Escuela de Medicina Fundaci\u00f3n Favaloro Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-9659","authenticated-orcid":false,"given":"Jose Maria","family":"Remes\u2010Troche","sequence":"additional","affiliation":[{"name":"Universidad Veracruzana Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Ruiz","family":"de Le\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Universidad Complutense Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-6369","authenticated-orcid":false,"given":"Julio\u00a0P\u00e9rez","family":"de la Serna","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Universidad Complutense Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Marin","sequence":"additional","affiliation":[{"name":"University Hospital Germans Trias i Pujol Motility and Functional Gut Disorders Unit Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Universitat Autonoma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-6270","authenticated-orcid":false,"given":"Jordi","family":"Serra","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) University Hospital Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12467"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116483"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-79"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dow028"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000731"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91428-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010502"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.212423"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13297"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13221"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.10.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.958096"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13287"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13827"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.12.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.04.231"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12889"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"e14025","DOI":"10.1111\/nmo.14025","article-title":"Validation and psychometric evaluation of the Spanish version of Brief Esophageal Dysphagia Questionnaire (BEDQ): results of a multicentric study","volume":"33","author":"Cisternas D","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14014"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04142.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12125"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12204"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_9_28_1","volume-title":"Parametric and Nonparametric Measures. Quantitative Applications in the Social Sciences","author":"Chen PY","year":"2002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0344-y"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9656-z"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.045"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00686.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13088"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000536"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14228","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T20:31:16Z","timestamp":1699302676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/nmo.14228"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14228","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"2021-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14228"}}