{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:19:25Z","timestamp":1787761165075,"version":"build-2784847793"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007511","name":"Universidad Rey Juan Carlos","doi-asserted-by":"publisher","award":["PREDOC20\u2010054"],"award-info":[{"award-number":["PREDOC20\u2010054"]}],"id":[{"id":"10.13039\/501100007511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008433","name":"Consejer\u00eda de Educaci\u00f3n, Juventud y Deporte, Comunidad de Madrid","doi-asserted-by":"publisher","award":["PEJD\u20102017\u2010PRE\/BMD\u20103924"],"award-info":[{"award-number":["PEJD\u20102017\u2010PRE\/BMD\u20103924"]}],"id":[{"id":"10.13039\/501100008433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2019\u2010111510RB\u2010I00"],"award-info":[{"award-number":["PID2019\u2010111510RB\u2010I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reaction to stress is an adaptive response necessary for survival. When stressors are repeated, the organism adapts, although these adaptive responses can become dysregulated and result in disease, causing gastrointestinal (GI) disorders. Radiographic methods allow the non\u2010invasive study of how a given factor affects GI transit in the same animal at different time points. These methods have never been applied to study the consequences of stress on GI motor function and their dependency on time and stimulus. Therefore, our aim was to characterize, using radiographic techniques, the effect on GI transit of cold\u2010restraint (CR) and forced swim (FS) stress applied acutely and subchronically in the rat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Wistar rats (260\u2013330\u00a0g) were submitted to FS or CR stress, during 1 (acute) or 4 (subchronic) consecutive days. To study GI transit, radiographic methods were used. Radiographs were taken 0\u201324\u00a0h after barium intragastric administration on the 1st or 4th day of stress, which was applied 1\u00a0h after contrast.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute FS or CR slowed down gastric and small intestinal emptying but had opposite effects in the caecum: CR tended to accelerate barium transit and feces formation while FS tended to slow these parameters down. When the stimuli were applied subchronically, GI transit was not completely normalized in most of the studied parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>Mild stress alters GI transit differently depending on the nature of the stressor and its duration. Exposure to mild stressors should be considered as contributing factors to different functional GI disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14232","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T11:30:35Z","timestamp":1628681435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-9292","authenticated-orcid":false,"given":"Ana","family":"Bagues","sequence":"first","affiliation":[{"name":"Department of Basic Health Sciences Universidad Rey Juan Carlos (URJC Alcorc\u00f3n Spain"},{"name":"High Performance Research Group in Experimental Pharmacology (PHARMAKOM\u2010URJC URJC Alcorc\u00f3n Spain"},{"name":"Unidad Instituto de Qu\u00edmica M\u00e9dica (IQM Consejo Superior de Investigaciones Cient\u00edficas (CSIC Asociada I+D+i del Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7488-2451","authenticated-orcid":false,"given":"Yolanda","family":"Lopez\u2010Tofi\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences Universidad Rey Juan Carlos (URJC Alcorc\u00f3n Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut\u2010URJC URJC Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-6883","authenticated-orcid":false,"given":"Carlos","family":"Galvez\u2010Roble\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences Universidad Rey Juan Carlos (URJC Alcorc\u00f3n Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut\u2010URJC URJC Alcorc\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-8795","authenticated-orcid":false,"given":"Raquel","family":"Abalo","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences Universidad Rey Juan Carlos (URJC Alcorc\u00f3n Spain"},{"name":"Unidad Instituto de Qu\u00edmica M\u00e9dica (IQM Consejo Superior de Investigaciones Cient\u00edficas (CSIC Asociada I+D+i del Madrid Spain"},{"name":"High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut\u2010URJC URJC Alcorc\u00f3n Spain"},{"name":"Grupo de Trabajo de Ciencias B\u00e1sicas en Dolor y Analgesia de la Sociedad Espa\u00f1ola del Dolor Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"issue":"7","key":"e_1_2_8_2_1","first-page":"61","article-title":"Neural control of chronic stress adaptation","volume":"8","author":"Herman JP","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00045"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.163"},{"key":"e_1_2_8_5_1","unstructured":"Daily Life \u2010 The American Institute of Stress. Accessed September 1 2020.https:\/\/www.stress.org\/daily\u2010life"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15346"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0271-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5772\/52066"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90231-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821324-7.00012-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.07.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1990.258.3.G329"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.09.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(93)90116-W"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.04.021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2008.05.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13621"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.10.043"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90189-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13651"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)90055-8"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22390"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.03.031"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00017-3"},{"key":"e_1_2_8_25_1","unstructured":"National Center for Biotechnology Information.PubChem Compound Summary for CID 24414 Barium sulfate. Accessed October 1 2020.https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Barium\u2010sulfate"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2016.02.007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2016_118"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12704"},{"issue":"3","key":"e_1_2_8_29_1","first-page":"2303","article-title":"Medial prefrontal cortex exacerbates gastric dysfunction of rats upon restraint water\u2010immersion stress","volume":"20","author":"Zhao DQ","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2016.11.001"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.122"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.368"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2153571"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14157"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00103"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.01.008"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114542022"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12725"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18202"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i5.737"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.01.020"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90928.2008"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000127196"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890903067418"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.076109"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-003-0526-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12755"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.05.018"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.61.280"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01040.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.4.507"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skaa041"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2014.01.008"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1139\/y89-084"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-011-9793-z"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T10:54:49Z","timestamp":1693220089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/nmo.14232"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14232","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]},"assertion":[{"value":"2021-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14232"}}