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The recent application of high\u2010resolution manometry catheters with closely spaced sensors to other gut segments has been highly successful. The objective of the present study was to determine the feasibility of a jejunal high\u2010resolution manometry method and to carry out a descriptive analysis of normal jejunal motor function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 36\u2010channel high\u2010resolution water\u2010perfused manometry catheter (MMS\u2010Laborie, Enschede, The Netherlands) was orally placed in the jejunum of 18 healthy subjects (10 men, eight women; 21\u201338 age range). Intestinal motility was recorded during 5\u00a0h, 3 during fasting, and 2 after a 450\u00a0kcal solid\u2010liquid meal. Analysis of motility patterns was supported by computerized tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>All healthy subjects except one showed at least one complete migrating motor complex during the 3\u00a0h fasting period. Phase III activity lasted 5\u00a0\u00b1\u00a01\u00a0min and migrated aborally at a velocity of 7\u00a0\u00b1\u00a03\u00a0cm\/min. High\u2010resolution spatial analysis showed that during phase III each individual contraction propagated rapidly (75\u00a0\u00b1\u00a037\u00a0cm\/min) over a 32\u00a0\u00b1\u00a010\u00a0cm segment of the jejunum. During phase II, most contractile activity corresponded to propagated contractile events which increased in frequency from early to late phase II (0.5\u00a0\u00b1\u00a00.9 vs 2.5\u00a0\u00b1\u00a01.3 events\/10\u00a0min, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). After meal ingestion, non\u2010propagated activity increased, whereas propagated events were less frequent than during late phase II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Jejunal motility analysis with high\u2010resolution manometry identifies propagated contractile patterns which are not apparent with conventional manometric catheters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14240","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T10:18:35Z","timestamp":1628677115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Propagation patterns of jejunal motor activity measured by high\u2010resolution water\u2010perfused manometry"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-1539","authenticated-orcid":false,"given":"Luis 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