{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:44:24Z","timestamp":1781617464237,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic has led to unprecedented disruptions in healthcare. Functional gastrointestinal and motility disorders (FGIMD) are associated with significant healthcare utilization. The clinical implications of these healthcare disruptions due to the COVID\u201019 pandemic on clinical outcomes in patients with FGIMD are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of patients with three common FGIMD (irritable bowel syndrome [IBS], gastroparesis, functional dyspepsia [FD]) tested for SARS\u2010CoV\u20102 to describe alterations in gastrointestinal symptoms, medication use, and healthcare utilization during and before the pandemic and factors associated with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The prevalence of COVID\u201019 during the pandemic (03\/2020\u201309\/2020) was 3.20% (83\/2592) among patients with FGIMD, 3.62% in IBS (57\/1574), 3.07% in gastroparesis (23\/749), and 2.44% in FD (29\/1187) at our institution. Patients with FGIMD had increased abdominal pain, nausea\/vomiting, diarrhea, constipation, and weight loss (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) along with increased proton pump inhibitor, H2 blocker, and opioid use (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Both inpatient hospitalizations and outpatient visits (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and number of diagnostic tests including cross\u2010sectional imaging (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), and upper and lower endoscopies (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) were significantly higher during the pandemic as compared to 6\u00a0months prior. Diarrhea\u2010predominant IBS was positively (OR 2.37, 95% CI 1.34\u20134.19, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) associated with COVID\u201019, whereas functional dyspepsia was negatively (OR 0.46, 95% CI 0.27\u20130.79, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Patients with common functional gastrointestinal and motility disorders have reported more gastrointestinal symptoms during the COVID\u201019 pandemic with concurrent increased medication use and healthcare utilization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14243","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T11:03:02Z","timestamp":1628679782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Gastrointestinal symptoms and healthcare utilization have increased among patients with functional gastrointestinal and motility disorders during the COVID\u201019 pandemic"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6037-2883","authenticated-orcid":false,"given":"John","family":"Gubatan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-2400","authenticated-orcid":false,"given":"Thomas","family":"Zikos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Spear Bishop","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-3727","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Gottfried","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laren","family":"Becker","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Habtezion","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-5012","authenticated-orcid":false,"given":"Leila","family":"Neshatian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2020-003421"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3386\/w27621"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","unstructured":"AhnS KimS&KohKChanges in healthcare utilization spending and perceived health during COVID\u201319: A longitudinal study from Singapore. 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