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We examined these issues in a longitudinal follow\u2010up study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected complete demographic, gastrointestinal symptom, and psychological comorbidity data at baseline from 1372 adults who met Rome IV criteria for one of the five functional bowel disorders. At 12\u00a0months, we collected data regarding gastrointestinal symptoms, psychological comorbidity, consultation behavior, and treatment commenced. We examined prognosis and stability of all five functional bowel disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>At baseline, 811 (59.1%) individuals met Rome IV criteria for irritable bowel syndrome (IBS), 76 (5.5%) functional constipation (FC), 199 (14.5%) functional diarrhea (FDr), 130 (9.5%) functional abdominal bloating or distension (FABD), and 156 (11.4%) unspecified functional bowel disorder (UFBD). In total, 782 (57.0%) were successfully followed up. Individuals with IBS at baseline were significantly more likely to report symptoms compatible with anxiety, depression, or somatoform\u2010type behavior (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 for all analyses) at baseline and follow\u2010up compared with those with the other four functional bowel disorders. IBS was the most stable functional bowel disorder; 319 (70.6%) of 452 participants still met criteria for IBS at 12\u00a0months, compared with 14 (34.1%) of 41, 43 (35.5%) of 121, 26 (33.8%) of 77, and 37 (40.7%) of 91 for FC, FDr, FABD, and UFBD, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Individuals with Rome IV\u2010defined IBS exhibited higher levels of anxiety, depression, or somatoform\u2010type symptom reporting. IBS was the most stable and the likeliest disorder that the other four functional bowel disorders would fluctuate to.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14268","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T05:48:17Z","timestamp":1631857697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characteristics of, and natural history among, individuals with Rome IV functional bowel disorders"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-5604","authenticated-orcid":false,"given":"Vivek C.","family":"Goodoory","sequence":"first","affiliation":[{"name":"Leeds Institute of Medical Research at St. James's University of Leeds Leeds UK"},{"name":"Leeds Gastroenterology Institute St. James's University Hospital Leeds 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