{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:43:23Z","timestamp":1790034203209,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015766","name":"Danone Nutricia Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elimination of key foods restricts dietary options in eosinophilic esophagitis (EoE) patients. Addition of amino acid\u2010based formula (AAF) to an elimination diet might facilitate adherence and, therefore, enhance efficacy of dietary management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether addition of AAF to a four\u2010food elimination diet (FFED) is more effective than FFED alone in decreasing eosinophilia, endoscopic signs, and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized controlled trial enrolled 41 adult patients with active EoE (\u226515 eosinophils (eos) per high power field (hpf)) at baseline biopsy. Subjects were randomized (1:1 ratio) to groups given a FFED or FFED with addition of AAF providing 30% of their daily energy needs (FFED\u00a0+\u00a0AAF). Histological disease activity, endoscopic signs, symptoms, and disease\u2010related quality of life (EoEQoL) were measured at baseline and after 6\u00a0weeks of intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (60% male, age 34.5 (interquartile range (IQR) 29\u201342.8\u00a0years)) were randomized to FFED (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) or FFED\u00a0+\u00a0AAF (<jats:italic>n<\/jats:italic>\u00a0=\u00a021); 40 participants completed the diet. Complete histological remission (&lt;15\u00a0eos\/hpf) was achieved in 48% of FFED\u00a0+\u00a0AAF subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) vs. 25% of FFED subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.204). Peak eosinophil counts (PEC) decreased significantly in both groups between baseline and week 6, but the change in PEC between groups was not different (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.130). A significant but similar endoscopic and symptomatic reduction was observed in both groups (all; <jats:italic>p<\/jats:italic>&lt;0.05). Total EoEQoL scores significantly improved in the FFED\u00a0+\u00a0AAF group between baseline and week 6 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), and not in the FFED group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of AAF to a FFED did not lead to a larger decrease in PEC between baseline and 6\u00a0weeks, but may result in a significant improvement of QoL in adult EoE patients NL6014 (NTR6778).<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14291","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T11:28:09Z","timestamp":1637234889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of amino acid\u2010based formula added to four\u2010food elimination in adult eosinophilic esophagitis patients: A randomized clinical trial"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-6270","authenticated-orcid":false,"given":"Willemijn E.","family":"de Rooij","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berber","family":"Vlieg \u2013 Boerstra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics OLVG  Amsterdam The Netherlands"},{"name":"Department of Nutrition &amp; Dietetics Hanze University of Applied Sciences  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijn J.","family":"Warners","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht and St. Antonius Hospital Nieuwegein  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen T.J.","family":"Van Ampting","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty C. A. M.","family":"van Esch","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"},{"name":"Division of Pharmacology Utrecht Institute for Pharmaceutical Sciences Faculty of Science Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone R. B. M.","family":"Eussen","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296781"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15231"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13129"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13165"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90637-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.202"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.11.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.02.015"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.015"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0052-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821cf503"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)60729-4"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.664"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14290"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.468"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13953"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00885-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.08.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.006"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.038"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.036"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.11.032"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.048"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01067-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04519.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-5-S3-P41"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-5-S3-P151"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301817"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.048"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.042"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617707095"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.023"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.026"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)37223-3"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(21)01009-X"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(13)60552-1"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.062"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7043011"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344398"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107673"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.10.001"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00405.2015"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.11.001"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.07.006"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.09.007"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.025"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308815"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:29:54Z","timestamp":1692826194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,18]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/nmo.14291"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14291","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,18]]},"assertion":[{"value":"2021-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14291"}}