{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:13:52Z","timestamp":1790230432044,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to limited treatment options, many patients with diabetic gastroparesis (DG) or idiopathic gastroparesis (IG) experience inadequate symptom control resulting in increased health\u2010care resource utilization (HRU) and associated costs. We compared all\u2010cause HRU and health\u2010care costs over the 3\u00a0years after patients\u2019 first gastroparesis diagnosis with that of matched controls without gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly diagnosed adults with DG or IG were identified in Optum's de\u2010identified Clinformatics<jats:sup>\u00ae<\/jats:sup> Data Mart Database (Q1\u20102007 to Q1\u20102019). Patients with DG\/IG were matched 1:1 to controls using a mixed approach of exact matching and propensity score matching. The index date was the first gastroparesis diagnosis for cases or randomly selected for controls. All\u2010cause HRU and direct health\u2010care costs per person\u2010year (PPY) were compared between DG\/IG cases and controls in Years 1\u20133 post\u2010index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Demographics and comorbidities were balanced between patients with gastroparesis (<jats:italic>n<\/jats:italic>\u00a0=\u00a018,015 [DG]; <jats:italic>n<\/jats:italic>\u00a0=\u00a014,305 [IG]) and controls. In each of the Years 1\u20133 post\u2010index, patients with DG or IG had significantly higher annual HRU and costs versus controls (mean total cost differences PPY: DG Year 1 $34,885, Year 2 $28,071, Year 3 $25,606; IG Year 1 $23,176, Year 2 $16,627, Year 3 $14,396) (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Across all 3\u00a0years, DG\/IG cohorts had approximately twice the costs of controls. HRU and costs were highest in Year 1 post\u2010index for both DG and IG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The economic burden of gastroparesis remains high several years after diagnosis, emphasizing the need for chronic treatment to effectively manage symptoms and consequently reduce the burden of this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14366","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T09:10:14Z","timestamp":1648631414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Health\u2010care resource use and costs associated with diabetic and idiopathic gastroparesis: A claims analysis of the first 3\u00a0years following the diagnosis of gastroparesis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-2294","authenticated-orcid":false,"given":"Yaozhu J.","family":"Chen","sequence":"first","affiliation":[{"name":"Takeda Development Center Americas, Inc.  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Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4904-4891","authenticated-orcid":false,"given":"Henry P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"Temple University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000320"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01942.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000220"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2014.11.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026665728213"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-018-0454-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01658.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.503"},{"key":"e_1_2_9_10_1","unstructured":"McCallumR.Gastroparesis 2017\u2010There is effective therapy and prevention is at hand.2017. 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