{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:27:18Z","timestamp":1762543638690,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001829","name":"Universiteit Utrecht","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015766","name":"Danone Nutricia Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015766","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophilic esophagitis (EoE) is an allergen\u2010mediated disease and elimination diets have proven to be effective to obtain clinical and histological remission. However, the effect of elimination diets on specific EoE transcripts and their clinical correlates is relatively unknown. The main aim of the study was to evaluate the effect of dietary treatment (four\u2010food elimination diet [FFED]) with or without addition of amino acid\u2010based formula (AAF) on a variety of pro\u2010\/anti\u2010inflammatory, epithelial\/barrier function and remodeling\/fibrosis\u2010related markers of disease activity and clinical correlates (eosinophils, symptoms, and endoscopic signs) in adult EoE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an analysis of biopsy samples and data collected during a randomized controlled trial with an elimination diet in adult patients with active EoE (\u226515 eosinophils [eos] per high\u2010power field [hpf]). Demographics, symptoms (SDI\u2010score), endoscopic signs (EREFS) and peak eosinophil counts\/hpf were recorded at baseline and after 6\u00a0weeks of treatment. Transcripts of 10 indicated genes were measured (qPCR) and compared to clinical correlates at baseline and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Forty patients (pooled FFED\u00a0+\u00a0FFED\u00a0+\u00a0AAF) (60% male, age 34.5 (interquartile range [IQR] 29\u201342.8\u00a0years) completed the diet. Peak eosinophil counts\/hpf, symptoms and endoscopic signs were significantly decreased after 6\u00a0weeks dietary treatment. DSG\u20101\u00a0levels were significantly upregulated from baseline to week 6, whereas IL\u201013, CAPN\u201014, IL\u20105, IL\u201010, CCL\u201026, POSTN, TSLP, CPA\u20103, and TGF\u2010\u03b2 were significantly downregulated after 6\u00a0weeks of diet (all; &lt;0.01). Prior to treatment, upregulation of CAPN\u201014 and lower levels of DSG\u20101 were associated with clinical fibrotic phenotypes, whereas upregulation of IL\u201010 was linked to food impaction phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings strongly suggest that elimination diets, besides a clinical and histological response, are associated with a broad transcriptional response at the level of the esophageal epithelium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14367","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T18:34:10Z","timestamp":1654454050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gene expression and clinical outcomes after dietary treatment for eosinophilic esophagitis: a prospective study"],"prefix":"10.1111","volume":"34","author":[{"given":"Willemijn E.","family":"de Rooij","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara A. P.","family":"Diks","sequence":"additional","affiliation":[{"name":"Division of Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijn J.","family":"Warners","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht and st. Antonius Hospital Nieuwegein  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen T. J. Van","family":"Ampting","sequence":"additional","affiliation":[{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty C. A. M.","family":"van Esch","sequence":"additional","affiliation":[{"name":"Division of Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht The Netherlands"},{"name":"Danone Nutricia Research  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology Amsterdam University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296781"},{"key":"e_1_2_9_5_1","first-page":"1419","article-title":"Idiopathic eosinophilic 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