{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:09:58Z","timestamp":1778123398357,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006509","name":"VSB Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, a new high\u2010definition (or three\u2010dimensional \u201c3D\u201d) high\u2010resolution anorectal manometry (3D\u2010ARM) catheter has been introduced. This catheter allows for a more detailed visualization of the anal canal. However, its clinical utility and tolerability in children with constipation are unknown. Our primary objective was to evaluate the agreement between findings from solid\u2010state high\u2010resolution anorectal manometry (HR\u2010ARM) and 3D\u2010ARM. Secondary objectives were to investigate if 3D\u2010ARM has additional value over HR\u2010ARM and to evaluate patient and provider experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective pilot study including children (8\u201318\u00a0years of age) with functional constipation scheduled for anorectal manometry. Children underwent HR\u2010ARM and 3D\u2010ARM consecutively. We compared manometry results of both procedures and collected data on patient and provider experience via self\u2010developed questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Data of ten patients were analyzed (60% female, median age 14.9\u00a0years). In the majority of patients, ARMs were performed awake (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 80%). In two patients, the recto\u2010anal inhibitory reflex (RAIR) was visualized during HR\u2010ARM but not during 3D\u2010ARM. Anal canal resting pressures were significantly higher during 3D\u2010ARM compared to HR\u2010ARM (median 77\u00a0mmHg [IQR 59\u201394] vs. 69\u00a0mmHg [IQR 51\u201391], respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037). No significant anatomical or muscular abnormalities were visualized during the 3D\u2010ARM. The majority of children identified the 3D\u2010ARM as the more unpleasant (5\/7 [71%]) and more painful procedure (6\/7 [86%]) and therefore preferred the HR\u2010ARM (4\/7 [57%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In our patient sample, 3D\u2010ARM was associated with more discomfort without providing more useful information and even resulted in an inconsistent visualization of the RAIR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14370","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T13:49:20Z","timestamp":1649080160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Do we need an extra dimension? A pilot study on the use of three\u2010dimensional anorectal manometry in children with functional constipation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-9354","authenticated-orcid":false,"given":"Desiree F.","family":"Baaleman","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"},{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children\u2019s Hospital Amsterdam UMC University of Amsterdam &amp; VU University  Amsterdam The Netherlands"},{"name":"Gastroenterology and Hepatology Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam UMC Univ of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-8447","authenticated-orcid":false,"given":"Mana H.","family":"Vriesman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"},{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children\u2019s Hospital Amsterdam UMC University of Amsterdam &amp; VU University  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children\u2019s Hospital Amsterdam UMC University of Amsterdam &amp; VU University  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neetu","family":"Bali","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla H.","family":"Vaz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desale","family":"Yacob","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2768-3353","authenticated-orcid":false,"given":"Peter L.","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-0968","authenticated-orcid":false,"given":"Ilan J. N.","family":"Koppen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Nationwide Children\u2019s Hospital  Columbus Ohio USA"},{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children\u2019s Hospital Amsterdam UMC University of Amsterdam &amp; VU University  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"issue":"121","key":"e_1_2_10_2_1","first-page":"e126","article-title":"Prevalence of functional defecation disorders in children: a systematic review and meta\u2010analysis","volume":"198","author":"Koppen IJN","year":"2018","journal-title":"J Pediatr"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.15171\/mejdd.2017.87"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181afcdc3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0335-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12944"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13125"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002000"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001595"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.01.008"},{"issue":"7","key":"e_1_2_10_11_1","first-page":"2981","article-title":"Three\u2010dimensional high\u2010resolution anorectal manometry in children after surgery for anorectal disorders","volume":"25","author":"Banasiuk M","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.361"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002819"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12944"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12397"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-43268-7_10"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13797"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.185"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01700.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296139"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12950"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4466-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-019-03297-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03206-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00827.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14137"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:58:27Z","timestamp":1692691107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,4]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/nmo.14370"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14370","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,4]]},"assertion":[{"value":"2022-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14370"}}