{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:05:51Z","timestamp":1781787951006,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Functional constipation (FC) and irritable bowel syndrome constipation type (IBS\u2010C) share many similarities, and it remains unknown whether they are distinct entities or part of the same spectrum of disease. Magnetic resonance imaging (MRI) allows quantification of intraluminal fecal volume. We hypothesized that colonic volumes of patients with FC would be larger than those of patients with IBS\u2010C, and that both patient groups would have larger colonic volumes than healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on validated questionnaires, three groups of participants were classified into FC (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), IBS\u2010C (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), and HC (<jats:italic>n<\/jats:italic>\u00a0=\u00a019). The colonic volume of each subject was determined by MRI. Stool consistency was described by the Bristol stool scale and colonic transit times were assessed with radiopaque makers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Overall, total colonic volumes were different in the three groups, HC (median 629\u00a0ml, interquartile range (IQR)(562\u2013868)), FC (864\u00a0ml, IQR(742\u2013940)), and IBS\u2010C (520\u00a0ml IQR(489\u2013593)) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Patients with IBS\u2010C had lower colonic volumes than patients with FC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and HC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.019), but there was no difference between FC and HC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.10). Stool consistency was similar in the two patient groups, but patients with FC had longer colonic transit time than those with IBS\u2010C (117.6\u00a0h versus 43.2\u00a0h,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with IBS\u2010C have lower total colonic volumes and shorter colonic transit times than patients with FC. Future studies are needed to confirm that colonic volume allows objective distinction between the two conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14374","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T08:50:30Z","timestamp":1649148630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Colonic volume in patients with functional constipation or irritable bowel syndrome determined by magnetic resonance imaging"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-4307","authenticated-orcid":false,"given":"Mette Winther","family":"Klinge","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"},{"name":"Diagnostic Centre Silkeborg Regional Hospital Silkeborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Krogh","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-7430","authenticated-orcid":false,"given":"Esben Bolvig","family":"Mark","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn Mohr","family":"Drewes","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lau","family":"Brix","sequence":"additional","affiliation":[{"name":"Department of Radiology Diagnostic Centre Silkeborg Regional Hospital Silkeborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Isaksen","sequence":"additional","affiliation":[{"name":"Department of Radiology Diagnostic Centre Silkeborg Regional Hospital Silkeborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milda","family":"Dedelaite","sequence":"additional","affiliation":[{"name":"Department of Radiology Aalborg University Hospital Aalborg Denmark"},{"name":"King\u00b4s College Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Br\u00f8ndum","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Radiology Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte Vinskov","family":"Fynne","sequence":"additional","affiliation":[{"name":"Diagnostic Centre Silkeborg Regional Hospital Silkeborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04273.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000135929.78074.8c"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.67"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0954"},{"key":"e_1_2_10_6_1","unstructured":"Foundation R.Rome IV questionaire https:\/\/theromefoundation.org\/rome\u2010iv\/rome\u2010iv\u2010questionnaire\/"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01642.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05259.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.12.010"},{"issue":"15","key":"e_1_2_10_10_1","first-page":"307","article-title":"Guidelines\u2010Rome III diagnostic criteria for functional gastrointestinal disorders","volume":"2006","author":"Foundation R","year":"2006","journal-title":"J Gastrointest Liver Dis"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.1.94"},{"key":"e_1_2_10_12_1","first-page":"1855","article-title":"Behandling af kronisk obstipation hos b\u00f8rn \u2013 en gennemgang af et Cochranereview. Ugeskr","volume":"175","author":"Pedersen CE","year":"2013","journal-title":"L\u00e6ger"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"e13731","DOI":"10.1111\/nmo.13731","article-title":"Enteric cholinergic neuropathy in patients with diabetes: Non\u2010invasive assessment with positron emission tomography","volume":"31","author":"Klinge MW","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12673"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.538"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11060974"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13400"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12784"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-015-0475-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.818"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01535722"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809095938"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12243"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.062"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.060"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2018.27"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750024698"},{"key":"e_1_2_10_30_1","first-page":"299","article-title":"Variability of gastrointestinal transit in healthy women and men","volume":"39","author":"Degen LP","year":"1996","journal-title":"Henry James in Context"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199003000-00003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12461"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26628"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90837-7"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T17:01:51Z","timestamp":1700413311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/nmo.14374"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14374","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]},"assertion":[{"value":"2021-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14374"}}