{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:37:24Z","timestamp":1789677444519,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1 DK78924"],"award-info":[{"award-number":["RO1 DK78924"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal methods for measuring and analyzing anal resting and squeeze pressure with high\u2010resolution manometry (HRM) are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anal resting and squeeze pressures were measured with HRM in 90\u00a0healthy women, 35 women with defecatory disorders (DD), and 85 with fecal incontinence (FI). Pressures were analyzed with Manoview\u2122 software and a customized approach. Resting pressures measured for 20, 60, and 300\u00a0s were compared. During the squeeze period, (3 maneuvers, 20\u00a0s each), the squeeze increment, which was averaged over 5, 10, 15, and 20\u00a0s, and squeeze duration were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to healthy women, the anal resting pressure, squeeze pressure increment, and squeeze duration were lower in FI (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.04) but not in DD. The 20, 60, and 300\u00a0s resting pressures were strongly correlated (concordance correlation coefficients\u00a0=\u00a00.96\u20130.99) in healthy and DD women. The 5\u00a0s squeeze increment was the greatest; 10, 15, and 20\u00a0s values were progressively lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The squeeze pressure increment and duration differed (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) among the three maneuvers in healthy and DD women but not in FI women. The upper 95th percentile limit for squeeze duration was 19.5\u00a0s in controls, 19.9\u00a0s in DD, and 19.3\u00a0s in FI. Adjusted for age, resting pressure, and squeeze duration, a greater squeeze increment was associated with a lower risk of FI versus health (OR, 0.96; 95% CI, 0.94\u20130.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that anal resting and squeeze pressures can be accurately measured over 20\u00a0s. In most patients, one squeeze maneuver is probably sufficient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14383","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T18:23:50Z","timestamp":1650911030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Optimizing techniques for measuring anal resting and squeeze pressures with high\u2010resolution manometry"],"prefix":"10.1111","volume":"34","author":[{"given":"Nicholas R.","family":"Oblizajek","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) 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Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Feuerhak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent R.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) 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