{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:04:16Z","timestamp":1793059456611,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010DK122280andR01\u2010DK125680"],"award-info":[{"award-number":["R01\u2010DK122280andR01\u2010DK125680"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies with functional endoluminal imaging probe (EndoFLIP<jats:sup>\u00ae<\/jats:sup>) measure physiologic characteristics of the pylorus. EndoFLIP<jats:sup>\u00ae<\/jats:sup> has the potential to select optimal candidates for gastric peroral endoscopic myotomy (G\u2010POEM). Normative values of the pylorus using EndoFLIP<jats:sup>\u00ae<\/jats:sup> have not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four healthy volunteers (20\u201356\u00a0years old; 15 females) underwent unsedated, transoral EndoFLIP<jats:sup>\u00ae<\/jats:sup> measurements of the pylorus after 8\u00a0h of fasting. Measurements of diameter (DM), balloon pressure, and distensibility index (DI) of the pylorus were obtained twice over 5\u00a0min at 40, 50, and 60\u00a0ml balloon distensions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Pyloric DM at 40, 50, and 60\u00a0ml balloon distensions were 13.0\u00a0\u00b1\u00a02.5, 14.3\u00a0\u00b1\u00a01.8, and 17.2\u00a0\u00b1\u00a02.0\u00a0mm, respectively. DM with 60\u00a0ml distension was notably higher than with 40 and 50\u00a0ml distensions. Pyloric DI at 40, 50, and 60\u00a0ml distensions were 10.9\u00a0\u00b1\u00a04.8, 11.3\u00a0\u00b1\u00a05.8, and 11.1\u00a0\u00b1\u00a04.3\u00a0mm<jats:sup>2<\/jats:sup>\/mm Hg, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.86). Linear regression and Bland\u2013Altman plots showed similar distribution of the DM and DI during the second minute compared with the full 5\u2010min measurements at 50\u00a0ml distension, as well as between two sequential measurements using 50\u00a0ml distension. With 50\u00a0ml balloon distension, intraindividual coefficients of variation (COV<jats:sub>intra<\/jats:sub>) for DM and DI were 13.8% and 29.6%, respectively, and interindividual COV (COV<jats:sub>inter<\/jats:sub>) were 12.6% and 51.3%, respectively. Similar reproducibility was obtained with 40\u00a0ml balloon distension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Unsedated EndoFLIP<jats:sup>\u00ae<\/jats:sup> can be used to characterize human fasting pyloric diameter and distensibility, with best performance observed with 40\u00a0ml and 50\u00a0ml distensions and data collection during the second minute. Normative values reported serve as reference values for future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14386","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T18:19:54Z","timestamp":1650910794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Fasting pyloric diameter and distensibility by functional endoluminal imaging probe in unsedated healthy volunteers"],"prefix":"10.1111","volume":"34","author":[{"given":"Ting","family":"Zheng","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-9386","authenticated-orcid":false,"given":"Kia","family":"Vosoughi","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Busciglio","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tebay","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane","family":"Burton","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-7514","authenticated-orcid":false,"given":"Michael","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90262-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0812-1458"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322756"},{"key":"e_1_2_9_5_1","first-page":"10","article-title":"Endoscopic pyloromyotomy (G\u2010POEM) improves symptoms in patients with refractory gastroparesis \u2013 a randomized sham controlled trial","volume":"9","author":"Hustak RMJ","year":"2021","journal-title":"United Eur Gastroenterol J"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324631"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.04.228"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0628-6639"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.12.030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1311-0859"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08441-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13892"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.01.044"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.072"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e3283413211"},{"issue":"11","key":"e_1_2_9_17_1","first-page":"995","article-title":"Effects of propofol and fentanyl on duodenal motility activity in pigs","volume":"46","author":"Schnoor J","year":"2005","journal-title":"Can Vet J"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000130852.53082.D5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2019.03.006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19200"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13053"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62169-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62245-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06510-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12522"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13980"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14386","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T07:59:35Z","timestamp":1692691175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,25]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/nmo.14386"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14386","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,25]]},"assertion":[{"value":"2022-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14386"}}