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The vagus nerve modulates gastric peristalsis and carries afferent sensory information to brainstem nuclei, specifically the nucleus tractus solitarii (NTS). Here, we combine MRI assessment of gastric kinematics with measures of NTS functional connectivity to the brain in patients with FD and healthy controls (HC), in order to elucidate how gut\u2013brain axis communication is associated with FD pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Functional dyspepsia and HC subjects experienced serial gastric MRI and brain fMRI following ingestion of a food\u2010based contrast meal. Gastric function indices estimated from 4D cine MRI data were compared between FD and HC groups using repeated measure ANOVA models, controlling for ingested volume. Brain connectivity of the NTS was contrasted between groups and associated with gastric function indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Propagation velocity of antral peristalsis was significantly lower in FD compared to HC. The brain network defined by NTS connectivity loaded most strongly onto the Default Mode Network, and more strongly onto the Frontoparietal Network in FD. FD also demonstrated higher NTS connectivity to insula, anterior cingulate and prefrontal cortices, and pre\u2010supplementary motor area. NTS connectivity was linked to propagation velocity in HC, but not FD, whereas peristalsis frequency was linked with NTS connectivity in patients with FD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>Our multi\u2010modal MRI approach revealed lower peristaltic propagation velocity linked to altered brainstem\u2010cortical functional connectivity in patients suffering from FD suggesting specific plasticity in gut\u2013brain communication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.14396","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T04:34:10Z","timestamp":1652416450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cine gastric\n                    <scp>MRI<\/scp>\n                    reveals altered\n                    <scp>Gut\u2013Brain<\/scp>\n                    Axis in Functional Dyspepsia: gastric motility is linked with brainstem\u2010cortical\n                    <scp>fMRI<\/scp>\n                    connectivity"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8837-5218","authenticated-orcid":false,"given":"Roberta","family":"Sclocco","sequence":"first","affiliation":[{"name":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Radiology, Harvard Medical School  Charlestown Massachusetts USA"},{"name":"Department of Radiology Logan University  Chesterfield Missouri USA"},{"name":"Scott Schoen and Nancy Adams Discovery Center for Recovery from Chronic Pain Spaulding Rehabilitation Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Radiology, Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Staley","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Radiology, Harvard Medical School  Charlestown Massachusetts USA"},{"name":"Department of Gastroenterology and Center for Neurointestinal Health Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Radiology, Harvard Medical School  Charlestown Massachusetts USA"},{"name":"Korean Institute of Oriental Medicine  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Center for Neurointestinal Health Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bolender","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Radiology, Harvard Medical School  Charlestown Massachusetts USA"},{"name":"Department of Gastroenterology and Center for Neurointestinal Health Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Coll\u2010Font","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Department of Medicine Massachusetts General Hospital, Harvard Medical School  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman W.","family":"Kettner","sequence":"additional","affiliation":[{"name":"Department of Radiology Logan University  Chesterfield Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Massachusetts General Hospital  Charlestown Massachusetts USA"},{"name":"Department of Medicine Massachusetts General Hospital, Harvard Medical School  Charlestown Massachusetts USA"},{"name":"Division of Health Sciences and Technology Harvard\u2010Massachusetts Institute of Technology  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braden","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Center for Neurointestinal Health Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Napadow","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A. 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