{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:23:06Z","timestamp":1793823786766,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005930","name":"ASCRS Research Foundation","doi-asserted-by":"publisher","award":["T000216N"],"award-info":[{"award-number":["T000216N"]}],"id":[{"id":"10.13039\/100005930","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A total mesorectal excision for rectal cancer\u2014although nerve\u2010 and sphincter\u2010sparing\u2014can give rise to significant bowel symptoms, commonly referred to as low anterior resection syndrome (LARS). The exact pathophysiology of this syndrome still remains largely unknown, and the impact of radical surgery on colonic motility has only been scarcely investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010resolution colon manometry was performed in patients, 12\u201324\u2009months after restoration of transit. Patients were divided into two groups: patients with major LARS and no\/minor LARS, according to the LARS\u2010score. Colonic motor patterns were compared, and the relationship of these patterns with the LARS\u2010scores was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Data were analyzed in 18 patients (9 no\/minor LARS, 9 major LARS). Cyclic short antegrade motor patterns did occur more in patients with major LARS (total: <jats:italic>p<\/jats:italic>\u00a0=\u20090.022; post\u2010bisacodyl: <jats:italic>p<\/jats:italic>\u00a0=\u20090.004) and were strongly correlated to LARS\u2010scores after administering bisacodyl (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). High amplitude propagating contractions (HAPC's) that started in the proximal colon and ended in the mid\u2010section of the colon occurred significantly less in patients with major LARS compared with patients with no\/minor LARS (<jats:italic>p<\/jats:italic>\u00a0=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>The occurrence of more cyclic short antegrade motor patterns and less HAPC's (from the proximal to the mid\u2010colon) is more prevalent in patients with major LARS. These findings help to understand the differences in pathophysiology in patients developing major versus no\/minor bowel complaints after TME for rectal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14432","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T10:43:55Z","timestamp":1658486635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring the pathophysiology of <scp>LARS<\/scp> after low anterior resection for rectal cancer with high\u2010resolution colon manometry"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-5993","authenticated-orcid":false,"given":"Anne","family":"Asnong","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences Faculty of Movement and Rehabilitation Sciences  Leuven 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