{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:30Z","timestamp":1753878630801,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI14\/01703"],"award-info":[{"award-number":["PI14\/01703"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interaction between gut stimuli may induce symptom overlap in patients with functional gastrointestinal disorders. The aim is to determine the effect of increased volumes of colonic contents on gastric sensory\/motor responses and satiety in patients with constipation\u2010predominant irritable bowel syndrome (IBS\u2010C) and overlapping dyspeptic symptoms, and a cohort of healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 15 patients with IBS\u2010C and 10 healthy subjects, the effect of real versus sham colonic filling with gas (1080\u2009ml) on gastric sensitivity (measured by stepwise distensions of the stomach), gastric compliance, abdominal perception, and nutrient drink tolerance was studied on separate days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In healthy subjects, colonic gas filling induced an increment in gastric sensitivity to distension (mean score 2.0\u2009\u00b1\u20090.2 before, and 3.0\u2009\u00b1\u20090.4 after; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038). In IBS, basal sensitivity was greater and remained unchanged after colonic gas filling (score 4.0\u2009\u00b1\u20090.1 and 3.8\u2009\u00b1\u20090.3, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 vs. basal in health). Colonic gas infusion induced abdominal symptoms that were significantly greater in IBS\u2010C (score 2.6\u2009\u00b1\u20090.1) than in health (score 1.7\u2009\u00b1\u20090.4; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027), with minor changes in gastric tone, and no changes in gastric compliance in both groups. Colonic filling produced a profound reduction in nutrient drink tolerance in IBS (791\u2009\u00b1\u200987\u2009ml sham filling, 491\u2009\u00b1\u200958\u2009ml gas filling; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but only a minor reduction in health (940\u2009\u00b1\u200970\u2009ml sham filling, 860\u2009\u00b1\u200994\u2009ml gas filling; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.223).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The volume of the colonic contents modulates satiety in patients with IBS\u2010C, due to a general visceral pan\u2010hypersensitivity. These effects should be considered in the choice of treatment for constipation in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14433","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T13:19:15Z","timestamp":1658409555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of intracolonic volume on gastric sensory\u2010motor responses in constipation\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"34","author":[{"given":"Noemi","family":"Caballero","sequence":"first","affiliation":[{"name":"Motility and Functional Gut Disorders Unit University Hospital Germans Trias i Pujol  Badalona Spain"},{"name":"Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Marin","sequence":"additional","affiliation":[{"name":"Motility and Functional Gut Disorders Unit University Hospital Germans Trias i Pujol  Badalona Spain"},{"name":"Autonomous University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Riu","sequence":"additional","affiliation":[{"name":"Motility and Functional Gut Disorders Unit University Hospital Germans Trias i Pujol  Badalona Spain"},{"name":"Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Leal","sequence":"additional","affiliation":[{"name":"Motility and Functional Gut Disorders Unit University Hospital Germans Trias i Pujol  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-6270","authenticated-orcid":false,"given":"Jordi","family":"Serra","sequence":"additional","affiliation":[{"name":"Motility and Functional Gut Disorders Unit University Hospital Germans Trias i Pujol  Badalona Spain"},{"name":"Autonomous University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Barcelona Spain"},{"name":"Digestive System Research Unit University Hospital Vall d'Hebr\u00f3n  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.421"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.04.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000196827"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i31.4848"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212683"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.4.365"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.4.G578"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8690193"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.036"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02141.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312361"},{"volume-title":"Forth","year":"2016","author":"Functional Gastrointestinal Disorders","key":"e_1_2_11_14_1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00875.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.579bw.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13378"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.75"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.158162"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28656"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70006-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.062869"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.1.14"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1708"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90739-4"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90057-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13408"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.408"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00511.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212678"},{"key":"e_1_2_11_32_1","first-page":"242","volume-title":"Sleisenger & Fordtran, Gastrointestinal and Liver Disease","author":"Azpiroz F","year":"2016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.060"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19072"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.11.022"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.014"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00020.2010"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70133-7"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13762"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0517-x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.202"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:50:40Z","timestamp":1692676240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/nmo.14433"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14433","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"type":"print","value":"1350-1925"},{"type":"electronic","value":"1365-2982"}],"subject":[],"published":{"date-parts":[[2022,7,21]]},"assertion":[{"value":"2021-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14433"}}