{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:37:43Z","timestamp":1792291063815,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Although high\u2010resolution manometry (HR_ARM) is commonly used to diagnose defecatory disorders, its intraindividual day\u2010to\u2010day reproducibility is unknown. Since these measurements entail voluntary effort, this study aimed to evaluate the intraindividual day\u2010to\u2010day reproducibility of HR_ARM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 22 healthy women (35\u2009years [14] mean [SD]) and 53 constipated patients\u00a0(42\u2009years [13], 46 women), the rectal balloon expulsion time (BET), and anorectal pressures were measured with HR_ARM on 2\u2009days separated by a median (interquartile range) of 15\u2009days (11\u201353) in healthy and 40\u2009days (8\u201375) in constipated patients. Anorectal pressures were evaluated at rest (20\u2009s), during squeeze, and during\u00a0evacuation. Rectal sensation was also evaluated in constipated patients. The agreement between both measurements was evaluated with Lin's concordance correlation coefficient (CCC) and other tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among constipated patients, the anal resting (mean CCC [95%CI] 0.62 [0.43\u20130.76]) and squeeze pressures (CCC 0.65 [0.47\u20130.79]), rectoanal gradient during evacuation (CCC 0.42 [0.17\u20130.62]), and rectal sensory thresholds (CCC for urgency 0.72 [0.52\u20130.84]) were concordant. Between days 1 and 2, one or more outcomes, characterized as normal or abnormal, differed in 79% of constipated patients, i.e., anal resting and squeeze pressures, the gradient, and the rectal BET differed in, respectively, 25%, 19%, 36%, and 10% of constipated patients. The rectal BET was prolonged in three healthy persons (both days) and either on 1\u2009day (six patients) or 2\u2009days (33 patients) in constipated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While HR_ARM variables and the BET are reproducible within healthy and constipated persons, the outcome on repeat testing differed in 79% of constipated patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14438","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T10:24:20Z","timestamp":1661509460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reproducibility of high\u2010resolution manometry among healthy and constipated persons"],"prefix":"10.1111","volume":"34","author":[{"given":"Rahul","family":"Mishra","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misha","family":"Gautam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Oblizajek","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-0390","authenticated-orcid":false,"given":"Adil E.","family":"Bharucha","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.034"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13679"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001507"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14335"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13591"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.12.034"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12950"},{"key":"e_1_2_10_9_1","first-page":"22","article-title":"Intra\u2010subject variability in high resolution anorectal manometry using the London classification: diagnostic and therapeutic implications","volume":"22","author":"Triadafilopoulos G","year":"2022","journal-title":"Dig Dis Sci"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.08.036"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13910"},{"key":"e_1_2_10_12_1","first-page":"8","article-title":"Abdomino\u2010anal dyscoordination in defecatory disorders","volume":"8","author":"Srinivasan SG","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.257"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14383"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13597"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12038"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14341"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.03.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.08.034"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2021.10.002"}],"container-title":["Neurogastroenterology &amp; 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