{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:03Z","timestamp":1790517423657,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scintigraphy is used for overall assessment of gastric emptying. Adherence to an international consensus protocol is recommended to ensure quality; however, this has not been widely adopted because preparation of the \u201cegg\u2010beater\u201d meal is inconvenient in clinical practice. In this report, we audit the tolerability and the results of gastric emptying scintigraphy with the 400\u2009ml Tc\u201099\u2009m\u2010labeled liquid nutrient Nottingham Test Meal (NTM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Results from 330 consecutive adult, non\u2010diabetic patients with dyspeptic symptoms referred for gastric scintigraphy were analyzed. Gastric half\u2010emptying time (T50) and validated measurements of early\u2010 and late\u2010phase gastric emptying were acquired. Postprandial sensations of fullness, bloating, heartburn, nausea, and epigastric pain were recorded using 100\u2009mm visual analog scales (VAS) before and 0, 30, and 90\u2009min after NTM ingestion. Results were compared with those previously obtained in healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Almost all (98%) of the patients were able to consume the 400\u2009ml NTM. Considering early\u2010 and late\u2010phase gastric emptying, frequently observed patterns included normal early\u2010 with slow late\u2010phase (25%) and fast early\u2010 with slow late\u2010phase emptying (27%). Abnormal score of fullness and\/ or dyspeptic symptoms were observed in 88% of dyspeptic patients. Abnormal fullness at T0 (after completed drink ingestion) was associated with slow late phase of gastric emptying, especially in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric scintigraphy with the NTM is simple to perform and well tolerated. Whether the identified abnormal gastric emptying patterns could predict different treatment outcome in patients with functional dyspepsia is the subject of ongoing prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14454","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T06:01:23Z","timestamp":1662703283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non\u2010diabetic dyspeptic patients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-5528","authenticated-orcid":false,"given":"Peter D.","family":"Hay","sequence":"first","affiliation":[{"name":"Medical Physics and Clinical Engineering Nottingham University Hospitals NHS Trust Nottingham 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