{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:43:07Z","timestamp":1792395787872,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oro\u2010pharyngeal pathophysiology, including upper esophageal sphincter (UES) and pharyngeal disorders, can be assessed by pharyngeal high\u2010resolution manometry impedance (P\u2010HRM\u2010I). We aimed to establish methodology to diagnose disorders utilizing P\u2010HRM\u2010I, hypothesizing that the objective measures could be used to diagnose disordered deglutition evidenced by greater aspiration scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0509, 18\u201391\u2009years) were compared to controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0120, 20\u201394\u2009years). Variables measuring UES relaxation, UES opening extent, intrabolus pressure, and pharyngeal contractile strength were derived for 10\u00a0ml liquid swallows. Three associated pharyngeal pressurization patterns, which may be indicative of obstructed flow, were characterized: pan\u2010pressurization (Type 1), distal compartmentalized pressurization (Type 2), and transient pressurization (Type 3). Deglutitive aspiration was determined from video fluoroscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      UES relaxation pressure was best able to differentiate patients from controls (\n                      <jats:italic>T<\/jats:italic>\n                      6.528,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Patients with abnormal relaxation pressure (&gt;8\u2009mmHg) more frequently exhibited pharyngeal pressurization patterns and had adjunct evidence of reduced luminal distensibility (high intrabolus pressure and\/or reduced UES opening). Utilizing this information, a diagnostic scheme was devised identifying 138 patients with UES disorder. A further 96 patients without evidence of UES disorder had abnormally weak pharyngeal pressures, confirming propulsive disorder. Amongst a sub\u2010sample of 320 patients undergoing video fluoroscopy, those with pharyngeal pressurizations and adjunct evidence of reduced UES relaxation and\/or distensibility had higher aspiration scores (Chi\u2010square 60.169,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>P\u2010HRM\u2010I can provide evidence for UES disorder based on pharyngeal pressurization patterns and abnormal findings for UES relaxation pressure, UES opening, and intrabolus pressure. Measuring pharyngeal contractility requires further optimization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.14461","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T11:49:06Z","timestamp":1663588146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Using high resolution manometry impedance to diagnose upper esophageal sphincter and pharyngeal motor disorders"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7378","authenticated-orcid":false,"given":"Taher","family":"Omari","sequence":"first","affiliation":[{"name":"Flinders Health and Medical Research Institute and College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-1137","authenticated-orcid":false,"given":"Charles","family":"Cock","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute and College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"},{"name":"Department of Gastroenterology &amp; Hepatology, Flinders Medical Centre Southern Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8137-9179","authenticated-orcid":false,"given":"Peter","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-8373","authenticated-orcid":false,"given":"Michal Marcin","family":"Szczesniak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7440-592X","authenticated-orcid":false,"given":"Mistyka","family":"Schar","sequence":"additional","affiliation":[{"name":"Flinders Health and Medical Research Institute and College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-6704","authenticated-orcid":false,"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Neurogastroenterology &amp; Motility University Hospitals Leuven  Leuven Belgium"},{"name":"Translational Research Centre Gastrointestinal Disease (TARGID) KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5675-7334","authenticated-orcid":false,"given":"Nathalie","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Neurogastroenterology &amp; Motility University Hospitals Leuven  Leuven Belgium"},{"name":"Translational Research Centre Gastrointestinal Disease (TARGID) KU Leuven  Leuven Belgium"},{"name":"Deglutology, Department of Neurosciences, ExpORL University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.49"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0552-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-013-9494-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_PERS-SIG13-2018-0007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_AJSLP-18-0039"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000491"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06507-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10023-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-020-10217-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17549507.2021.1975817"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10088-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1562-7107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27104"},{"key":"e_1_2_10_15_1","unstructured":"SwallowOT.Gateway\u2122 high resolution manometry 2021. 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