{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:27:35Z","timestamp":1788474455404,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A frequent, although not universal, feature of irritable bowel syndrome (IBS) is heightened sensitivity to mechanical stimulation of the rectum, termed rectal hypersensitivity (RH). Differences in RH\u2010based on sex, IBS subtype, IBS diagnostic criteria and age of population studied are incompletely understood. We aimed to determine whether IBS population had lower pain thresholds than healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched MEDLINE and EMBASE databases (1970\u20132021). Prospective studies that compared pain\/discomfort thresholds to mechanical rectal stimuli in IBS and healthy controls were included. Data were pooled for meta\u2010analyses and effect sizes were calculated with 95% confidence interval (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our search strategy identified 809 studies of which 32 studies met the inclusion criteria. Reduced rectal pain thresholds was more common in IBS patients compared to healthy controls with an effect size of 1.00 95% CIs (0.77\u20131.24) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200978.6%). The pediatric IBS population had lower pain thresholds than adult IBS populations (<jats:italic>p<\/jats:italic>\u00a0=\u20090.05) but no difference based on IBS diagnostic criteria, subtype or sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>The results suggest that reduced rectal pain threshold to experimental stimulation is far more common in IBS patients than healthy controls. Further research is required to understand the pathophysiological and therapeutic implications of rectal sensitivity such as its role in measuring response to treatment and prognosis in IBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14515","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T06:21:58Z","timestamp":1672122118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Factors influencing rectal hypersensitivity in irritable bowel syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-8044","authenticated-orcid":false,"given":"Christopher","family":"Roberts","sequence":"first","affiliation":[{"name":"Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London  London UK"},{"name":"Department of Paediatric Gastroenterology University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-4776","authenticated-orcid":false,"given":"Ahmed","family":"Albusoda","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-2640","authenticated-orcid":false,"given":"Adam D.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London  London UK"},{"name":"Mech\u2010Sense, Department of Gastroenterology Aalborg University Hospital  Aalborg Denmark"},{"name":"Institute of Applied Clinical Sciences University of Keele  Keele UK"},{"name":"Department of Gastroenterology University Hospitals of North Midlands NHS Trust  Stoke on Trent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-2065","authenticated-orcid":false,"given":"Qasim","family":"Aziz","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, Surgery and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine &amp; Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.1.125"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.12.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.053"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2010.505256"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14965"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0954"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.12.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2049463713479229"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90267-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02066.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12886"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13378"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13679"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.4.373"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.3.388"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.060"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_9_23_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.2.0 (Updated February 2017)","author":"Chandler J","year":"2017"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33601"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200220070-00003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16484"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldp026"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200602000-00007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20898"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.505"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.117390"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.94"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2005.02.007"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.5.670"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00276.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04503-7"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321530"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.039"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.049"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12163"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12489"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01295.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i27.3699"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.11.010"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12618-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.016"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12689"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617715851"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03918.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.110858"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8915872"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14515","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:28:42Z","timestamp":1692674922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/nmo.14515"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14515","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14515"}}