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New tools have been developed to identify pyloric dysfunction in routine care, including functional luminal impedance planimetry (FLIP). As such, a new therapeutic strategy targeting the pylorus, namely endoscopic pyloromyotomy (G\u2010POEM), has received increasing attention and emerged as a promising treatment for gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The present review details the involvement of the pyloric pathophysiology in gastroparesis, as well as clinical results of G\u2010POEM according to the current literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14529","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T10:07:35Z","timestamp":1672740455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Targeting the pylorus in gastroparesis: From physiology to endoscopic 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