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Little is known about how positive psychological factors in IBS relate to IBS symptoms, health\u2010related quality of life (HRQoL), or adherence to key health behaviors, such as physical activity and diet modification. Accordingly, per the ORBIT model of behavioral treatment development for chronic diseases, we explored potential connections between psychological constructs and IBS symptoms, health behavior engagement (physical activity and dietary modification), and HRQoL in a qualitative study to inform the development of a novel brain\u2013gut behavior therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants with IBS completed self\u2010report assessments and semi\u2010structured phone interviews about relationships between positive and negative psychological constructs, IBS symptoms, health behavior engagement, and HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a023; 57% female) ranged in age from 25 to 79 (mean age\u00a0=\u00a054). IBS subtypes were similarly represented (IBS\u2010diarrhea [<jats:italic>n<\/jats:italic>\u00a0=\u00a08], IBS\u2010constipation [<jats:italic>n<\/jats:italic>\u00a0=\u00a07], and IBS\u2010mixed [<jats:italic>n<\/jats:italic>\u00a0=\u00a08]). Participants described opposing relationships between positive and negative psychological constructs, IBS symptoms, health behavior engagement, and HRQoL, respectively, such that experiencing positive constructs largely mitigated IBS symptoms, boosted health behavior participation, and improved HRQoL, and negative constructs exacerbated symptoms, reduced health behavior participation, and worsened HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>Participants with IBS linked greater positive psychological well\u2010being to moderated IBS symptoms and better HRQoL and health behavior participation. An intervention to cultivate greater well\u2010being may be a novel way to mitigate IBS symptoms, boost health behavior participation, and improve HRQoL in IBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14531","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T05:45:21Z","timestamp":1674020721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Positive psychological well\u2010being: A novel concept for improving symptoms, quality of life, and health behaviors in irritable bowel syndrome"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-2032","authenticated-orcid":false,"given":"Elizabeth N.","family":"Madva","sequence":"first","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Neurointestinal Health, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie D.","family":"Bomm","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-3256","authenticated-orcid":false,"given":"Helen","family":"Burton\u00a0Murray","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Neurointestinal Health, Gastroenterology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-4290","authenticated-orcid":false,"given":"Kyle","family":"Staller","sequence":"additional","affiliation":[{"name":"Harvard 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