{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:41:47Z","timestamp":1789753307071,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The presence of high amplitude propagated contractions (HAPCs) measured by colonic manometry (CM) reflect an intact neuromuscular function of the colon. Bisacodyl and Glycerin are colonic stimulants that induce HAPCs and are used for the treatment of constipation. HAPCs characteristics with each drug have not been compared before. We aimed to compare the HAPC characteristics with Bisacodyl and Glycerin in children undergoing CM for constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective single\u2010center cross\u2010over study of children aged 2\u201318 years undergoing CM. All patients received both Glycerin and Bisacodyl during CM. They were randomized to group A with Bisacodyl first (<jats:italic>n<\/jats:italic>\u00a0=\u200922) and group B with Glycerin first (<jats:italic>n<\/jats:italic>\u00a0=\u200923), with 1.5 hours in between each dose. Differences in patient and HAPC characteristics between groups were summarized using descriptive statistics and compared using Chi\u2010square test or Wilcoxon rank sum test as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 45 patients were included. HAPCs post Bisacodyl had a longer duration of action (median of 40 vs 21.5 min, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001), longer propagation (median of 70 vs 60 cm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), and more HAPCs (median of 10 vs 5, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.0001) compared Glycerin. No differences were found in the HAPC amplitude and onset of action between both medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14544","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T17:35:42Z","timestamp":1677519342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High amplitude propagated contractions with Glycerin versus Bisacodyl: A within\u2010subject comparison in children undergoing colonic manometry"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-7630","authenticated-orcid":false,"given":"Sherief","family":"Mansi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracielle","family":"Bahia","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-0814","authenticated-orcid":false,"given":"Dhiren","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cardinal Glennon Children's Medical Center Saint Louis University School of Medicine  St Louis Missour USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev","family":"Dorfman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"El\u2010Chammas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology CCHMC  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology CCHMC  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha R.","family":"Santucci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahleb","family":"Graham","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kaul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Pediatrics Cincinnati Children's Hospital Medical Center (CCHMC)  Cincinnati Ohio USA"},{"name":"University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90166-A"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80229-X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2018.7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13110"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12944"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12019"},{"issue":"70","key":"e_1_2_12_8_1","first-page":"e78","article-title":"High\u2010resolution colonic manometry accurately predicts colonic neuromuscular pathological phenotype in pediatric slow transit constipation","volume":"25","author":"Giorgio V","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13851"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01230.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.1.17"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.209"},{"key":"e_1_2_12_13_1","first-page":"126","article-title":"Success of antegrade enemas in children with functional constipation","volume":"25","author":"Pensabene L","year":"2003","journal-title":"Pediatr Med Chir"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14123"},{"key":"e_1_2_12_15_1","first-page":"570","article-title":"pharmacokinetics and laxative effect of bisacodyl following administration of various dosage forms","volume":"38","author":"Roth W","year":"1988","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_12_16_1","first-page":"118","article-title":"Use of a contact laxative solution (Dulcolax) as an adjunct in colostomy control","volume":"30","author":"Stevenson TB","year":"1964","journal-title":"Am Surg"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00386.2019"},{"key":"e_1_2_12_18_1","unstructured":"Medicine. DIPGNUSNLo.Drug Information Portal: Glycerin. NIH U.S. National Library of Medicine;2019."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13050"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199810000-00006"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00347.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00209.2021"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301754"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12018"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nmo.14544","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:33:29Z","timestamp":1692578009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/nmo.14544"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14544","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,27]]},"assertion":[{"value":"2022-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14544"}}