{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:51:05Z","timestamp":1792813865818,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004690","name":"Minist\u00e8re de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both gastric electrical stimulation (GES) and gastric\u2010peroral endoscopic myotomy (G\u2010POEM) can be offered to patients with gastroparesis and predominant nausea and vomiting. The study's aim was to compare GES and G\u2010POEM efficacy on nausea and vomiting scores in patients with gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two multicenter cohorts of patients with medically refractory gastroparesis with predominant nausea and vomiting (defined as a score\u2009&gt;2 on nausea and vomiting subscale that varied from 0 to 4) were treated either with GES (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) or G\u2010POEM (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) and were followed for 24\u2009months (M). Clinical response was defined as a decrease of \u22651 point in nausea and vomiting subscale without premature exclusion due to switch from one to the other technique before M24. Changes in symptomatic scales and quality of life were also monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Patients from both groups were comparable although the mean score of nausea and vomiting subscale was higher in GES (3.0) compared to G\u2010POEM group (2.6; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). At M24, clinical response was achieved in 21\/34 (61.7%) patients with GES and in 21\/30 (70.0%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.60) patients with G\u2010POEM. Mean scores of nausea and vomiting subscale decreased at M24 in both GES (from 3.0 to 1.6; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and G\u2010POEM (from 2.6 to 1.2; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) groups, although there was no difference between groups (difference adjusted from baseline: \u22120.28 [\u22120.77; 0.19]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.24). Likewise, symptomatic and quality of life scores improved at M24 in both groups, without difference according to treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>At M24, we did not observe significant difference in efficacy of GES and G\u2010POEM in medically refractory gastroparesis with predominant nausea and vomiting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14565","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:19:46Z","timestamp":1679660386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Gastric electrical stimulation versus per\u2010oral pyloromyotomy for the treatment of nausea and vomiting associated with gastroparesis: An observational study of two cohorts"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9155","authenticated-orcid":false,"given":"Guillaume","family":"Gourcerol","sequence":"first","affiliation":[{"name":"Physiology and Gastroenterology Department, INSERM 1073\u2010CIC 1404 RouenUniversity Hospital  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department North Hospital AP\u2010HM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1858-8941","authenticated-orcid":false,"given":"Bruno","family":"Bonaz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department CHU  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Diabetology Department CHU  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6802-2121","authenticated-orcid":false,"given":"Frank","family":"Zerbib","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centre Medico\u2010chirurgical Magellan, INSERM CIC 1401 CHU de Bordeaux, H\u00f4pital Haut\u2010L\u00e9v\u00eaque, Universit\u00e9 de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-1591","authenticated-orcid":false,"given":"Francois","family":"Mion","sequence":"additional","affiliation":[{"name":"Physiology Department HCL  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Basile","sequence":"additional","affiliation":[{"name":"Physiology and Gastroenterology Department, INSERM 1073\u2010CIC 1404 RouenUniversity Hospital  Rouen 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