{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:43:41Z","timestamp":1784033021223,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to assess sex\u2010 and gender\u2010related differences in the epidemiology and impact of disorders of gut\u2013brain interaction (DGBI) in Poland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data used for the current analysis were derived from the Polish population sample of 2057 subjects (1030\u2009F, 1027\u2009M) collected via the Internet survey that included the Rome IV diagnostic questionnaire and 80 supplementary questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The overall prevalence of DGBI in Poland was 46.0% (51.7% in women and 40.3% in men, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Comparing women versus men, esophageal disorders were observed in 6.3% vs. 6.0%, respectively (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), gastroduodenal disorders in 14.0% vs. 7.8% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), bowel disorders in 44.3% vs. 33.9% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and anorectal disorders in 9.9% vs. 7.7% (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). The six most common DGBI included functional constipation 14.2%, functional dyspepsia 8.3%, proctalgia fugax 6.6%, functional bloating 4.8%, functional diarrhea 4.5%, and irritable bowel syndrome (IBS) 4.4%. All these disorders, except for functional diarrhea, were more common in women. The DGBI overlap was significantly higher in women than in men (16.7% vs. 11.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A higher number of overlapping DGBI correlated positively with IBS severity, higher level of somatization, anxiety and depression, poorer quality of life (QoL), and increased healthcare utilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>This is the first comprehensive report on significant sex\/gender\u2010related differences in the prevalence and burden of DGBI in Poland. The revealed differences between women and men with DGBI in the clinical profile, psychosocial variables, and healthcare utilization may have important diagnostic and therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14568","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T18:46:20Z","timestamp":1680115580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sex\u2010 and gender\u2010related differences in the prevalence and burden of disorders of gut\u2010brain interaction in Poland"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4678-8393","authenticated-orcid":false,"given":"Agata","family":"Mulak","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Wroclaw Medical University  Wroclaw 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