{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:10:51Z","timestamp":1793038251524,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Latin America, there are scarce data on the epidemiology of DGBI. The Rome Foundation Global Epidemiology Study (RFGES) Internet survey included 26 countries, four from Latin America: Argentina, Brazil, Colombia, and Mexico, with a 40.3% prevalence of Rome IV DGBI. We aimed at comparing the prevalence of DGBI and associated factors among these countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The frequency of DGBI by anatomical region, specific diagnoses, sex, age, diet, healthcare access, anxiety, depression, and HRQOL, were analyzed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects included Argentina <jats:italic>n<\/jats:italic>\u00a0=\u00a02057, Brazil\u00a0=\u00a02004, Colombia\u00a0=\u00a02007, and Mexico\u00a0=\u00a02001. The most common DGBI were bowel (35.5%), gastroduodenal (11.9%), and anorectal (10.0%). Argentina had the highest prevalence of functional diarrhea (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006) and IBS\u2010D; Brazil, esophageal, gastroduodenal disorders, and functional dyspepsia; Mexico functional heartburn (all &lt;0.001). Overall, DGBI were more common in women vs. men and decreased with age. Bowel disorders were more common in the 18\u201339 (46%) vs. 40\u201364\u2010year (39%) groups. Diet was also different between those with DGBI vs. those without with subtle differences between countries. Subjects endorsing criteria for esophageal, gastroduodenal, and anorectal disorders from Mexico, more commonly consulted physicians for bowel symptoms vs. those from Argentina, Brazil, and Colombia. General practitioners were the most frequently consulted, by Mexicans (50.42%) and Colombians (40.80%), followed by gastroenterologists. Anxiety and depression were more common in DGBI individuals in Argentina and Brazil vs. Mexico and Colombia, and they had lower HRQOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of upper and lower DGBI, as well as the burden of illness, psychological impact and HRQOL, differ between these Latin American countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14569","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T18:46:30Z","timestamp":1680115590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of the epidemiology of disorders of gut\u2013brain interaction in four Latin American countries: Results of The Rome Foundation Global Epidemiology Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-8542","authenticated-orcid":false,"given":"Max J.","family":"Schmulson","sequence":"first","affiliation":[{"name":"Laboratory of Liver, Pancreas and Motility (HIPAM)\u2010Unit of Research in Experimental Medicine, Faculty of Medicine Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7058-2574","authenticated-orcid":false,"given":"Gerardo A.","family":"Puentes\u2010Leal","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology Centro Hospitalario Serena del Mar  Cartagena de Indias Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2788-8121","authenticated-orcid":false,"given":"Luis","family":"Bustos\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro M\u00e9dico Bustos Fern\u00e1ndez  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8206-9121","authenticated-orcid":false,"given":"Carlos","family":"Francisconi","sequence":"additional","affiliation":[{"name":"Gastroenterology Division, Hospital de Cl\u00ednicas de Porto Alegre Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-4548","authenticated-orcid":false,"given":"Albis","family":"Hani","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital Universitario San Ignacio Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-6161","authenticated-orcid":false,"given":"Aurelio","family":"L\u00f3pez\u2010Colombo","sequence":"additional","affiliation":[{"name":"UMAE Hospital de Especialidades Centro M\u00e9dico Nacional Manuel Avila Camacho  Puebla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-3708","authenticated-orcid":false,"given":"Olafur S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-0689","authenticated-orcid":false,"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-3689","authenticated-orcid":false,"given":"Ami D.","family":"Sperber","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2021.04.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903045106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082013000700004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntx167"},{"key":"e_1_2_10_7_1","unstructured":"America DoC\u2010USo.The U.S.\u2010Mexico\u2010Canada Agreement (USMCA) entered into force on July 1 2020 replacing the North American Free Trade Agreement (NAFTA). 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