{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:45:13Z","timestamp":1780472713840,"version":"3.54.1"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dermatomyositis (DM) is a rare autoimmune disease characterized by distinctive skin rash, muscle inflammation with symmetrical and progressive muscle weakness, and elevated serum levels of muscle\u2010associated enzymes. DM may affect skeletal muscles involved in swallowing, leading to dysphagia, which can negatively impact individual's physical and psychosocial well\u2010being. Despite this, dysphagia in patients with DM remains poorly understood. This systematic review and meta\u2010analysis aimed to evaluate the prevalence and clinical features of dysphagia in patients with DM and juvenile DM (JDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four electronic databases were systematically searched until September 2022. Studies with patients with DM or JDM and dysphagia were included. The pooled prevalence of all included studies was calculated, and the clinical characteristics of dysphagia were qualitatively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Thirty\u2010nine studies with 3335 patients were included. The overall pooled prevalence of dysphagia was 32.3% (95% CI: 0.270, 0.373) in patients with DM and 37.7% (95% CI: \u22120.031, 0.785) in patients with JDM. Subgroup analyses revealed that Sweden had the highest prevalence (66.7% [95% CI: 0.289, 1.044]), whereas Tunisia had the lowest prevalence (14.3% [95% CI: \u22120.040, 0.326]). Moreover, South America had the highest prevalence (47.0% [95% CI: 0.401, 0.538]), whereas Africa had the lowest prevalence (14.3% [95% CI: \u22120.040, 0.326]). Dysphagia in patients with DM and JDM was characterized by both oropharyngeal and esophageal dysfunctions, with predominant difficulties in motility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our findings showed that dysphagia affects one in three patients with DM or JDM. However, the documentation on the diagnosis and management of dysphagia in the literature is inadequate. Our results highlighted the need to use both clinical and instrumental assessments to evaluate swallowing function in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14572","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T15:34:18Z","timestamp":1680536058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A systematic review and meta\u2010analysis on the prevalence and clinical characteristics of dysphagia in patients with dermatomyositis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-7976","authenticated-orcid":false,"given":"Ivy","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, Lee Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"},{"name":"Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4603-6407","authenticated-orcid":false,"given":"Christina Sze\u2010Man","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, Lee Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"},{"name":"Division of Dermatology, Department of Medicine Queen Mary Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.328"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120434"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-001-0113-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14998"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.0068"},{"issue":"11","key":"e_1_2_9_10_1","article-title":"Atypical presentation of dysphagia in a patient diagnosed later with dermatomyositis: a case report","volume":"13","author":"Elmdaah A","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2017-001860"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01671.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072150"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000054"},{"key":"e_1_2_9_15_1","unstructured":"HigginsJPT ThomasJ ChandlerJ et al.Cochrane Handbook for Systematic Reviews of Interventionsversion 6.0 (updated July 2019).2019. 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