{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:12:10Z","timestamp":1788412330102,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Real\u2010world data on the outcome of routine treatment for disorders of gut\u2010brain interaction (DGBI) in secondary care are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A longitudinal study of consecutive adult patients with various DGBI attending this institution's gastroenterology clinic was conducted. Following 2\u2009years of treatment, the proportion of patients with symptom improvement, details of clinical therapy, factors associated with and the impact of \u2018no symptom improvement\u2019 were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 289 patients (median age 68\u2009years; 64.7% females; 28.4% irritable bowel syndrome (IBS), 20.1% functional dyspepsia (FD), 8.7% functional constipation (FC), 42.9% overlap syndrome) were recruited. After 2\u2009years, 66.1% patients reported symptom improvement. Patients with overlap syndrome were less likely to have symptomatic improvement compared to those with a single DGBI (Overlap 55.6% vs IBS 74.4% vs FD 72.4% vs FC 76.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Reassurance was associated with symptom improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). On multivariate analysis, overlap syndrome remained significantly associated with a poorer outcome (OR 2.27, 95% CI 1.22\u20134.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.010), while providing reassurance was associated with a positive outcome (OR 0.30, 95% CI 0.16\u20130.56, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><jats:p>Only 25.6% and 14.9% of patients were referred for a low FODMAP diet and psychiatric intervention respectively. DGBI patients who had \u2018no improvement\u2019 were more likely to seek further GI consultations and had more work absenteeism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two\u2010thirds of DGBI patients in secondary care showed symptom improvement. Patients who were reassured had better symptom improvement, while those with an overlap syndrome were associated with a poorer outcome, resulting in greater healthcare consultation and work absenteeism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14602","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T18:16:15Z","timestamp":1682360175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical outcome of disorders of <scp>gut\u2010brain<\/scp> interaction in secondary care: A longitudinal study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-7546","authenticated-orcid":false,"given":"Kee Huat","family":"Chuah","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine University of Malaya  Kuala Lumpur 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