{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:51:39Z","timestamp":1776264699436,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The aim of the study was to evaluate the effect of an electronic positional therapy wearable device on nocturnal gastroesophageal reflux measured by pH\u2010impedance reflux monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center, prospective, interventional study in 30 patients with nocturnal reflux symptoms and a nocturnal esophageal acid exposure time (AET) \u22651.5% measured off acid\u2010suppressive medication by ambulatory pH\u2010impedance reflux monitoring. Patients were treated with an electronic positional therapy wearable device for 2\u2009weeks. The device vibrates in the right lateral decubitus position so it conditions patients to avoid that sleep position. After 2\u2009weeks treatment, the pH\u2010impedance study was repeated. Primary outcome was the change in nocturnal AET. Secondary outcomes include change in number of reflux episodes and reflux symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete data were available for 27 patients (13 females, mean age 49.8\u2009years). The median nocturnal AET decreased from 6.0% (IQR, 2.3\u201315.3) to 3.1% (0.1\u201310.8) after 2\u2009weeks of treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.079). The number of reflux episodes was significantly reduced after 2\u2009weeks of treatment (baseline: 8.0 (3.0\u201312.3) vs. end: 3.0 (1.0\u20138.0); <jats:italic>p<\/jats:italic>\u2009=\u20090.041). Treatment led to a statistically significant decrease in time spent in right lateral decubitus position (baseline: mean 36.9%\u2009\u00b1\u200915.2% vs. end: 2.7%\u2009\u00b1\u20098.2%; <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;0.001) and an increase in the left lateral decubitus position (baseline 29.2%\u2009\u00b1\u200914.8% vs. end: 63.3%\u2009\u00b1\u200921.9%; <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;0.001). Symptom improvement was reported by 70.4% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep positional therapy using an electronic wearable device promotes sleeping in the left lateral decubitus position and improves reflux parameters measured by pH\u2010impedance reflux monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14614","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T13:37:54Z","timestamp":1685367474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of sleep positional therapy on nocturnal gastroesophageal reflux measured by esophageal <scp>pH<\/scp>\u2010impedance monitoring"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-3551","authenticated-orcid":false,"given":"Jeroen M.","family":"Schuitenmaker","sequence":"first","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-5505","authenticated-orcid":false,"given":"Thijs","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-0116","authenticated-orcid":false,"given":"Marlies P.","family":"Schijven","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-6282","authenticated-orcid":false,"given":"Andr\u00e9 J. 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M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-0672","authenticated-orcid":false,"given":"Paul","family":"Fockens","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-2062","authenticated-orcid":false,"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology, Amsterdam Gastroenterology and Metabolism University Medical Centers Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903035745"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01279.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03180.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001588"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.02.058"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033290"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100511"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.458"},{"key":"e_1_2_11_12_1","unstructured":"Castor EDC.Castor Electronic Data Capture.2019.[online]. 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