{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:52:46Z","timestamp":1769161966393,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Functional dyspepsia (FD) is a heterogeneous functional gastrointestinal disorder (FGID) with a highly prevalent symptom complex. The aim of our study is to investigate the relation between symptoms of FD and results of gastric emptying (GE) breath test in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included patients (6\u201317\u2009years old) presented at the general gastroenterology outpatient clinic with dyspeptic symptoms (Rome IV criteria) and underwent careful history taking with clinical examination. A GE breath test with a<jats:sup>13<\/jats:sup>C\u2010octanoic acid labeled (250\u2009kcal) solid meal was performed and dyspepsia symptom scores, clarified using pictograms for postprandial fullness, bloating, belching, nausea, vomiting, epigastric pain and burning, were obtained every 15\u2009min ranging from 0 to 4 for a total of 240\u2009min. The severity of the complaints (overall and individual symptoms) as displayed by the symptom questionnaire was compared between normal and delayed GE groups. The relationship between GE time and the severity of FD symptoms was assessed using Mann\u2013Whitney test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty nine FD patients (55% girls; mean age: 11.9\u2009\u00b1\u20093.3\u2009years) participated in the study. Of these, 43% had delayed GE. The overall symptom severity in patients with delayed GE was similar to the symptoms of patients with a normal GE rate (149.5\u2009\u00b1\u200912.7 points vs. 123.9\u2009\u00b1\u20099.0;<jats:italic>p<\/jats:italic>\u2009=\u20090.19). Individual symptoms scores showed only nausea to be significantly increased in the group with delayed GE (21.5\u2009\u00b1\u20091.9 points vs. 33.2\u2009\u00b1\u20094.6;<jats:italic>p<\/jats:italic>\u2009=\u20090.048,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Especially in children with nausea as presenting symptom of FD, a low threshold should be withheld to perform a GE breath test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14620","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T09:39:46Z","timestamp":1686217186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nausea is the only symptom associated with delayed gastric emptying in pediatric functional dyspepsia patients"],"prefix":"10.1111","volume":"35","author":[{"given":"Marijke","family":"De\u00a0Keukelaere","sequence":"first","affiliation":[{"name":"Pediatric Department Imelda Hospital Bonheiden and University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Carbone","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit University Hospitals Leuven Leuven Belgium"},{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"van Hoeve","sequence":"additional","affiliation":[{"name":"Department of Pediatric gastroenterology, Hepatology and Nutrition University Hospitals Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit University Hospitals Leuven Leuven Belgium"},{"name":"Translational Research Center for Gastrointestinal Disorders (TARGID) University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Pediatric gastroenterology, Hepatology and Nutrition University Hospitals Leuven Leuven 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