{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:23:05Z","timestamp":1768530185405,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Low mean nocturnal baseline impedance (MNBI) values support gastroesophageal reflux disease (GERD) diagnosis. Recent data denote that age and obesity may affect MNBI. We aimed to evaluate diagnostic MNBI cutoffs as also the effect of aging and body mass index (BMI) on MNBI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total 311 patients (M\/F: 139\/172, mean age: 47\u2009\u00b1\u200913) referred for typical GERD symptoms that have undertaken both high\u2010resolution manometry (HRM) and pH\u2010Impedance studies off PPI were evaluated. MNBI at 3, 5, and 17\u2009cm over lower esophageal sphincter (LES) were evaluated. GERD was diagnosed if acid exposure time (AET) &gt;6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean BMI was 26.6\u2009\u00b1\u20095.9\u2009kg\/cm<jats:sup>2<\/jats:sup>. GERD was diagnosed in 39.2% and 13.5% had inconclusive GERD. MNBI was correlated to patients' age, BMI, AET, and the length of LES\u2010CD separation and at 3\u2009cm also to the total number of reflux and LES hypotension. In the multivariate analysis MNBI at 3 and 5\u2009cm was independently correlated only to age, BMI, and AET. Patients with definite GERD showed lower MNBI at 3\u2009cm compared with inconclusive GERD though both showed lower values when compared with GERD absence. At 3\u2009cm MNBI ability for diagnosing GERD was good (0.815, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 95% CI: 0.766\u20130.863) with an optimal cutoff point of 1281 Ohm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our study findings age and BMI affect independently lower esophageal MNBI values in patients evaluated for GERD. MNBI significantly aids toward GERD diagnosis though in a real\u2010life setting MNBI values much lower than the one previously proposed should be used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14626","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T05:58:55Z","timestamp":1687154335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of aging and obesity on esophageal mucosal integrity as measured by baseline impedance"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-825X","authenticated-orcid":false,"given":"Theodoros","family":"Voulgaris","sequence":"first","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Upper GI Physiology Unit Royal London Hospital, Wingate Institute of Neurogastroenterology, Blizard Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Upper GI Physiology Unit Royal London Hospital, Wingate Institute of Neurogastroenterology, Blizard Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-0523","authenticated-orcid":false,"given":"Daniel","family":"Sifrim","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Upper GI Physiology Unit Royal London Hospital, Wingate Institute of Neurogastroenterology, Blizard Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-4957","authenticated-orcid":false,"given":"Etsuro","family":"Yazaki","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Upper GI Physiology Unit Royal London Hospital, Wingate Institute of Neurogastroenterology, Blizard Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.233049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0689-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13777"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.06.026"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16481"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322627"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.793388"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615598426"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19183"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.629302"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150046"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.02.055"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2022.983412"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20277"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm17032"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325531"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20158"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T05:02:23Z","timestamp":1691989343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,18]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/nmo.14626"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14626","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,18]]},"assertion":[{"value":"2023-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14626"}}