{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:11:09Z","timestamp":1754194269475,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peptest is a noninvasive and convenient diagnostic kit for gastroesophageal reflux disease (GERD). We aimed to explore the application value of Peptest in the diagnosis of GERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients suspected of GERD all completed 24\u2009h pH\u2010impedance monitoring (24\u2009h MII\u2010pH) and then took proton pump inhibitor (PPI) 2\u2009weeks. The postprandial, post\u2010symptom and random salivary samples were taken. Receiver operating characteristic analysis was used to identify the best cutoff value of Peptest, to differentiate GERD patients from non\u2010GERD patients and the optimal sampling time of Peptest was analyzed. Reflux characteristics and esophageal motility between Peptest (+) group and Peptest (\u2212) group were compared in negative 24\u2009h MII\u2010pH patients. Peptest concentration were compared among non\u2010reflux, distal reflux, and proximal reflux groups according to 24\u2009h MII\u2010pH curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The area under the curve of post\u2010symptom Peptest was highest in three time points and the diagnostic specificity was 81.0% and sensitivity was 53.3% with the diagnostic value of 86\u2009ng\/mL. Compared with negative Peptest group, distal mean nocturnal baseline impedance was significantly lower, gastroesophageal junction contractile integral was substantially lower in positive Peptest group in negative 24\u2009h MII\u2010pH patients. The concentration of post\u2010symptom and postprandial Peptest increased gradually in the non\u2010reflux, distal reflux, and proximal reflux groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Peptest has a relatively low diagnostic value for GERD. Post\u2010symptom Peptset is the best sampling time with the optimal value of 86\u2009ng\/mL and may have auxiliary diagnostic value for negative 24\u2009h MII\u2010pH patients. Peptest may assist 24\u2009h MII\u2010pH in monitoring proximal reflux.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14627","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T05:55:55Z","timestamp":1687154155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The clinical application value of salivary pepsin in the diagnosis of gastroesophageal reflux diseases"],"prefix":"10.1111","volume":"35","author":[{"given":"Rongrong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Department of Medical Oncology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research &amp; The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nanjing Qixia District Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benchang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-9220","authenticated-orcid":false,"given":"Liuqin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.21360"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313589"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2074535"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12163"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.200063"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314722"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.01.031"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19032"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-022-00933-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19115"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00714-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307049"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doaa117"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0667-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30408"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12783"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-022-07496-7"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01663.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14075"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16481"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848211013484"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm21156"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.65066"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.13038"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001205"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000011"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28182"}],"container-title":["Neurogastroenterology &amp; 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