{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:59Z","timestamp":1753879199679,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastroesophageal reflux disease (GERD) is one of the most prevalent gastrointestinal diseases in the western world. Lifestyle modifications and proton pump inhibitors (PPIs) form the basis of the management of GERD. A subset of patients seeks for (natural) alternative therapies besides PPIs. benesco\u2122 is an over\u2010the\u2010counter nutrition based on quercetin which has a presumed positive effect on esophageal barrier function. Therefore we aim to assess the effect of benesco\u2122 on reflux symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a double\u2010blind randomized placebo\u2010controlled trial in participants with reflux symptoms. Participants were assigned randomly (1:1) to receive 6\u2009weeks of benesco\u2122 (three times daily one lozenge containing 200\u2009mg of quercetin) or placebo. The primary outcome was treatment success (\u226550% reduction in Reflux Disease Questionnaire Score). Secondary outcomes included GERD\u2010related quality of life, reflux\u2010free days and nights, and participant\u2010reported treatment success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>One hundred participants were randomized. Treatment success was seen in 18 (39%) of 46 participants in the intervention group versus 21 (47%) of 45 in the placebo group (<jats:italic>p<\/jats:italic>\u2009=\u20090.468). In the intervention group 10 (1\u201321) reflux\u2010free days were reported compared to 10 (2\u201325) in the placebo group (<jats:italic>p<\/jats:italic>\u2009=\u20090.673). In addition, 38 (34\u201341) versus 39 (35\u201342) reflux\u2010free nights were reported (<jats:italic>p<\/jats:italic>\u2009=\u20090.409).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In our trial benesco\u2122 showed no significant benefit over placebo at group level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14648","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T10:25:18Z","timestamp":1688984718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The clinical effect of <scp>benesco\u2122<\/scp> on reflux symptoms: A double\u2010blind randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-5505","authenticated-orcid":false,"given":"Thijs","family":"Kuipers","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centers Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-2019","authenticated-orcid":false,"given":"Renske A. B.","family":"Oude\u00a0Nijhuis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centers Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-3551","authenticated-orcid":false,"given":"Jeroen M.","family":"Schuitenmaker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centers Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-2062","authenticated-orcid":false,"given":"Albert J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centers Location University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Gastroenterology, Endocrinology and Metabolism  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-39"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.233049"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.469"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898633"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.194191"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13066"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00345.2013"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.014"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13750"},{"issue":"1","key":"e_1_2_14_15_1","article-title":"Adverse effects associated with proton pump inhibitor use","volume":"13","author":"Yibirin M","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.194044"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.752787"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.04.062"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12204"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.02.058"},{"key":"e_1_2_14_21_1","unstructured":"Castor Electronic Data Capture 2019. 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