{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:01:16Z","timestamp":1790744476341,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pyloric distensibility has been reported as a predictive measure in gastroparesis. Measures can be obtained either during endoscopy under anesthesia or in unsedated patients. However, the impact of anesthetic drugs on the results of pyloric characteristics remains unknown. The objective of the present study was to determine the impact of anesthetics on pyloric characteristics measured using EndoFLIP\u00ae in patients with gastroparesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with gastroparesis from three French tertiary centers were retrospectively analyzed. Patients with a previous history of pyloric intervention were not considered for analysis. Medical records were reviewed for the potential use of anesthetic drugs during EndoFLIP\u00ae measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>One hundred twenty\u2010five patients were included in the present study [median age: 55.0\u2009years (43.0\u201366.0)]. Thirty\u2010four patients (27.2%) had pyloric assessment without general anesthesia and 91 patients (72.8%) with general anesthesia. Pyloric pressure at 40\u2009mL of distension was higher in patients with general anesthesia in comparison with patients without general anesthesia [18.7 (13.0\u201325.6) mmHg vs. 15.4 (11.9\u201320.7) mmHg; <jats:italic>p<\/jats:italic>\u2009=\u20090.044)]. In multivariate analysis, suxamethonium chloride administration was associated with decreased pyloric distensibility (OR: 3.9; 95% CI: 1.3\u201311.4; <jats:italic>p<\/jats:italic>\u2009=\u20090.013) while ephedrine was rather associated with increased pyloric distensibility (OR: 0.3; 95% CI: 0.1\u20130.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.036).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>This study is the first to have found an impact of general anesthesia on pyloric measurement using the EndoFLIP\u00ae. Therefore, further studies are needed to confirm these findings, if possible, prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14651","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T05:54:31Z","timestamp":1690437271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of anesthetics on pyloric characteristics measured using the <scp>EndoFLIP<\/scp>\u00ae system in patients with gastroparesis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-7675","authenticated-orcid":false,"given":"Charlotte","family":"Desprez","sequence":"first","affiliation":[{"name":"Physiology Department CHU Rouen  Rouen France"},{"name":"Nutrition, Brain and Gut Laboratory, INSERM Unit 1073 Rouen University Hospital  Rouen 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