{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:51:57Z","timestamp":1793393517430,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastric electrical stimulation (GES) is an effective therapy in medically refractory chronic nausea and vomiting. GES is assumed to be a contraindication for pregnancy. We examined the safety of GES during pregnancy and its clinical impact on vomiting symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed in two tertiary centers including all female patients of childbearing age implanted with GES. Patients without pregnancy while on GES were asked about their desire and concerns about pregnancy. Patients who were pregnant while on GES therapy were interviewed about the course of the pregnancy and labor, as well as the health of the children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Among 91 patients implanted at childbearing age, 54 patients without pregnancy answered the questionnaire. Nine patients (16.7%) reported a desire for pregnancy and five patients (7.4%) reported worries about the safety of GES during pregnancy. Sixteen pregnancies were reported in 10 patients. All pregnancies ended in a live birth with premature birth in 12 pregnancies (75.0%). No health concern was currently noted in these children. No severe GES\u2010related complications occurred during pregnancy with only pain at the implantation site reported during 3 pregnancies (18.8%). The severity and frequency of nausea and vomiting significantly increased during the first trimester (<jats:italic>p<\/jats:italic>\u2009=\u20090.04 and <jats:italic>p<\/jats:italic>\u2009=\u20090.005, respectively) and decreased after the delivery, becoming lower than before the pregnancy (<jats:italic>p<\/jats:italic>\u2009=\u20090.044 and <jats:italic>p<\/jats:italic>\u2009=\u20090.011, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inferences<\/jats:title><jats:p>Patients are concerned regarding pregnancy while being treated with GES. No serious maternal or fetal complications related to GES were noted in our cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14657","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T06:29:08Z","timestamp":1691994548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastric electrical stimulation is safe during pregnancy and delivery: Results from a French cohort"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-7272","authenticated-orcid":false,"given":"Heithem","family":"Soliman","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Louis Mourier, DMU ESPRIT\u2010GHU AP\u2010HP\u2010Nord  Colombes France"},{"name":"Department of Physiology Universit\u00e9 de Rouen Normandie, INSERM, ADEN UMR1073, \u201cNutrition, Inflammation and Microbiota\u2010Gut\u2010Brain Axis\u201d, CHU Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha A.","family":"Schalla","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics HELIOS Kliniken GmbH  Rottweil Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy University Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-4158","authenticated-orcid":false,"given":"Beno\u00eet","family":"Coffin","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Assistance Publique\u2010H\u00f4pitaux de Paris, H\u00f4pital Louis Mourier, DMU ESPRIT\u2010GHU AP\u2010HP\u2010Nord  Colombes France"},{"name":"Centre de Recherche sur l'Inflammation Universit\u00e9 Paris Cit\u00e9, INSERM  Paris 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