{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:39:23Z","timestamp":1780483163793,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our main goals were to investigate the effects of L\u2010glutathione (1%) treatment in Walker\u2010256 tumor\u2010bearing rats by analyzing immunoreactive neurons (IR), responsive to the nNOS enzyme and 3\u2010Nitrotyrosine, in their jejunum myenteric plexus. Moreover, the oxidative state and inflammatory process in these animals were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four experimental groups were utilized: control (C), control treated with L\u2010glutathione (CGT), Walker\u2010256 tumor\u2010bearing rats (TW), and Walker\u2010256 tumor\u2010bearing rats treated with L\u2010glutathione (TWGT). After 14\u2009days of tumor inoculation, the jejunum was collected for immunohistochemical techniques and assessment of oxidative status. Plasma was collected to evaluate oxidative status and measure cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The TW group exhibited a decrease of reduced glutathione in their jejunum, which was prevented in the L\u2010glutathione treated TWGT group. TW animals presented pronounced oxidative stress by increasing levels of lipoperoxidation in their jejunum and malondialdehyde in their plasma; however, the L\u2010glutathione treatment in TWGT group was not able to avoid it. The total antioxidant capacity was altered in groups TW and TWGT, yet the last one had a better index in their plasma. The IL\u201010, and TNF\u2010\u03b1 levels increased in TWGT animals. The nNOS\u2010IR neuron density decreased in the jejunum myenteric plexus of the TW group, which was avoided in the TWGT group. The nNOS +3\u2010Nitrotyrosine neurons quantification did not show significative alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The treatment with L\u2010glutathione (1%) imposed an important defense to some parameters of oxidative stress induced by TW\u2010256, leading to neuroprotection to the loss in the nNOS\u2010IR neuron density.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14688","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:50:14Z","timestamp":1697219414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["L\u2010glutathione 1% promotes neuroprotection of nitrergic neurons and reduces the oxidative stress in the jejunum of rats with Walker\u2010256\u2010bearing tumor"],"prefix":"10.1111","volume":"35","author":[{"given":"Ana Paula","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Physiology 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