{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T23:41:54Z","timestamp":1775518914365,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytokines have been presumed to play an important role in the pathophysiology of functional dyspepsia (FD). Electroacupuncture (EA) has been used for FD treatment; however, its mechanisms remain largely unknown. This study aimed to (1) compare the plasma levels of cytokines, including tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20101\u03b2, IL\u20106, and IL\u201010, in \u201cFD\u201d rats with normal control rats; (2) investigate whether EA, using chronically implanted electrodes, could inhibit the release of these cytokines; and (3) explore the correlation of cytokine levels with plasma norepinephrine (NE) levels and gastric emptying (GE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A rodent model of FD was established via neonatal treatment with intragastric iodoacetamide. After 8\u2009weeks, the rats were implanted with electrodes at acupoint ST36 for EA. The plasma levels of cytokines and NE were measured using enzyme\u2010linked immunosorbent assay. We explored the correlations of cytokine levels with NE levels and GE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>(i) \u201cFD\u201d rats demonstrated increased levels of TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 each) compared with the control rats. (ii) EA significantly decreased the plasma levels of TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 in \u201cFD\u201d rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 each) compared with sham EA. (iii) The plasma levels of NE were positively correlated with those of IL\u20106 (<jats:italic>r<\/jats:italic>\u2009=\u20090.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and IL\u20101\u03b2 (<jats:italic>r<\/jats:italic>\u2009=\u20090.81, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), whereas NE levels and GE were negatively correlated with IL\u201010 levels (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.870, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 and <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.791, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EA inhibits the release of proinflammatory cytokines probably via the suppression of sympathetic activity in \u201cFD\u201d rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14702","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:49:16Z","timestamp":1700603356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Autonomic and cytokine mechanisms of acute electroacupuncture in a rodent model of functional dyspepsia"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-3177","authenticated-orcid":false,"given":"Sujuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology No. 983 Hospital of Chinese People's Liberation Army  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiying","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Michigan School of Medicine  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hepatology First Affiliated Hospital of Xi'an Jiao tong University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieyun","family":"Yin","sequence":"additional","affiliation":[{"name":"Transtimulation Research Inc.  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32115-2"},{"issue":"10","key":"e_1_2_10_3_1","first-page":"152","article-title":"Global dietary patterns and functional gastrointestinal disorders","volume":"7","author":"Axelrod CH","year":"2020","journal-title":"Children (Basel)"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16214"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01897.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.046"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.033"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318536"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01550-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.091"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000740"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01299.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.512"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59532-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm19186"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13381"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00256.2019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12602"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/904926"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01164.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1773-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01339"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1124"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013070"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12183"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151882"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00254.2016"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.093"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-014-1521-6"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12995"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.73"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01220.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18060"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019498"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02098.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30555"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053158"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.10.007"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00240.2007"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1229"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2007.11.003"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-411545-3.00014-6"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12856"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0783-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i5.1028"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(84)90071-7"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087897"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-004-0011-7"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2892"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2007.08.001"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.14702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T04:47:58Z","timestamp":1704948478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.14702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/nmo.14702"],"URL":"https:\/\/doi.org\/10.1111\/nmo.14702","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14702"}}