{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:56Z","timestamp":1753879316809,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK067872\u201019"],"award-info":[{"award-number":["T32 DK067872\u201019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypercontractile esophagus (HE) is a disorder of increased esophageal body contractile strength on high\u2010resolution esophageal manometry (HREM). Compartmentalized pressurization (CP) is a pattern with an isobaric contour of &gt;30\u2009mmHg extending from the contractile front to the lower esophageal sphincter on HREM. The relevance of CP to HE has yet to be explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed on 830 HREM studies of patients to identify HE. HE patients' CP status and symptoms by Eckardt score (ES) were reviewed. Diagnoses were made using Chicago Classification (CC) v4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Forty\u2010seven patients (5.6%) were identified as having HE by CCv3, 30 (3.6%) of which had HE by CCv4. 11\/30 HE patients had CP, and 19\/30 did not. CP was associated with chronic opioid use (36.4% vs. 5.3% <jats:italic>p<\/jats:italic>\u2009=\u20090.047). Presenting ES was greater for HE patients with CP (7 vs. 4). Seven HE patients with CP and 11 without CP were managed medically. ES after medical therapy was higher in HE patients with CP compared to those without CP (9 vs. 0). No HE patients with CP responded to medical therapy. Kaplan\u2013Meier analysis demonstrated significance of this association over time. 83% of all HE patients had all\u2010cause symptom remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>HE patients with CP are associated with a higher presenting ES. HE patients with CP do not respond to medical therapy, while HE patients without CP frequently do respond. CP in HE may have prognostic value in determination of treatment strategy for patients with HE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.14711","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:49:44Z","timestamp":1700603384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compartmentalized pressurization is a novel prognostic factor for hypercontractile esophagus"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-3243","authenticated-orcid":false,"given":"Andrew R.","family":"Leopold","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond E.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Division of Gastroenterology and Hepatology Veterans Affairs Maryland Healthcare System  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-5853","authenticated-orcid":false,"given":"Guofeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine University of Maryland School of Medicine  Baltimore Maryland USA"},{"name":"Division of Gastroenterology and Hepatology Veterans Affairs Maryland Healthcare System  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01311.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5036160"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13870"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13262"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.313"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15388"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13507"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13221"},{"key":"e_1_2_12_11_1","unstructured":"ZVU Guide.High resolution esophageal manometry analysis.2020. 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